Studies on Griseolic Acid Derivatives. V. Synthesis and Phosphodiesterase Inhibitory Activity of Substituted Derivatives of the Hydroxy Group at the 2'- or 7'-Position in Griseolic Acid(Organic,Chemical)

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概要

• 論文の詳細を見る

• Substituted derivatives of the hydroxy group at the 2'- or 7'-position in griseolic acid (1) were synthesized by selective substitution in order to study the relationship between structure and inhibitory activity against adenosine 3',5'-cyclic monophosphate (cAMP) or guanosine 3',5'-cyclic monophosphate (cGMP) phosphodiesterase (PDE). All of the derivatives which had a configurationally inverted substituent at the 2'-position instead of the hydroxy group were almost equal to natural griseolic acid in cAMP PDE inhibitory activity, except when the substituent was an amino group. On the other hand, substitution of 7'-OH with inversion tended to reduce the inhibitory activity a little.

• 公益社団法人日本薬学会の論文
• 1987-11-25

著者

• 室伏 良信

  Chemical Research Laboratories:sankyo Company Ltd.

• 山崎 光郎

  Biological Research Laboratories, Sankyo Co., Ltd.

• 木村 美佐子

  Chemical Research Laboratories:sankyo Company Ltd.

• 飯島 康輝

  Biological Research Laboratories

• 金子 正勝

  Chemical Research Laboratories

• 飯島 康輝

  Biological Research Laboratories:sankyo Co. Ltd.

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