Studies on Griseolic Acid Derivatives. VI. : Synthesis and Phosphodiesterase-Inhibitory Activity of 6- and N^1-Substituted Derivatives of Griseolic Acid
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概要
- 論文の詳細を見る
Twenty kinds of 6-substituted and five kinds of N^1-substituted griseolic acid derivatives were synthesized. The inhibitory activities of these compounds towards adenosine 3', 5'-cyclic monophosphate (cAMP) and guanosine 3', 5'-cyclic monophosphate (cGMP) phosphodiesterase (PDE) were investigated to clarify the structure-activity relationship. Substitution at the 6-position of griseolic acid caused a change of PDE IC_<50> from 0.16 to 206μM against cAMP PDE. Substitution at the N^1-position also caused a change of PDE IC_<50> from 0.16 to 127μM against cAMP PDE.
- 公益社団法人日本薬学会の論文
- 1988-04-25
著者
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室伏 良信
Chemical Research Laboratories:sankyo Company Ltd.
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山崎 光郎
Biological Research Laboratories, Sankyo Co., Ltd.
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木村 美佐子
Chemical Research Laboratories:sankyo Company Ltd.
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飯島 康輝
Biological Research Laboratories
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金子 正勝
Chemical Research Laboratories
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飯島 康輝
Biological Research Laboratories:sankyo Co. Ltd.
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