Synthesis of 9-(β-D-Arabinofuranosyl) adenine 5'-Phosphate starting from Adenosine 5'-Phosphate

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概要

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• 9-(β-D-Arabinofuranosyl) adenine 5'-phosphate was obtained from adenosine 5'-phosphate via the novel intermediate 8,2'-O-cycloadenosine 5'-phosphate. In contrast to the synthesis of 9-(β-D-arabinofuranosyl) adenine, it was difficult to cleave this compound by hydrogen sulfide directly to 8,2'-O-cycloadenosine 5'-phosphate because of a considerable degree of dephosphorylation. However N-acylated 8,2'-O-cycloadenosine 5'-phosphate was readily cleaved at the cyclo-bond by hydrogen sulfide. Desulfurization of 8-mercapto-9-(β-D-arabinofuranosyl) adenine 5'-phosphate gave the desired pure crystalline product.'

• 公益社団法人日本薬学会の論文
• 1977-08-25

著者

• 清水 文治

  Central Research Laboratories of Sankyo Co., Ltd.

• 木村 美佐子

  Chemical Research Laboratories:sankyo Company Ltd.

• 池原 森男

  Faculty Of Pharmaceutical Sciences Osaka University

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