Studies on Synthetic Nucleotides. IV. Preparation of L-β-Ribonucleosides and L-β-Ribonucleotides.
スポンサーリンク
概要
- 論文の詳細を見る
The chloromercuri salt of 6-benzamidopurine was condensed with 2,3,5-tri-O-benzoyl-DL-ribofuranosyl chloride, then the protecting groups removed, β-DL-adenosine was produced. β-DL-Adenosine was treated with nitrous acid to afford DL-inosine. β-DL-AMP was obtained by phosphorylation of β-DL-adenosine with phenylphosphorodichloridate. In a similar manner β-DL-IMP was obtained starting from β-DL-inosine. Attempts were made with success to obtain L-adenosine by incubation of DL-adenosine with a bacterial cell suspension (the strain used was PS-264,an unidentified stock culture of our laboratories). The incubation for 2〜3 days resulted in complete deamination and hydrolysis of D-adenosine whereas about 50% of L-adenosine remained unattacked and the rest was deaminated to give the corresponding L-inosine. On the other hand, when DL-AMP was incubated with a snake venom obtained from Trimeresurus flavoviridis, only D-antipode was dephosphorylated to D-adenosine and L-AMP left unchanged. L-AMP was separated from D-adenosine by ion exchange chromatography. L-IMP was also obtained from DL-IMP by the same method.
- 公益社団法人日本薬学会の論文
- 1967-12-25
著者
-
清水 文治
Central Research Laboratories of Sankyo Co., Ltd.
-
浅井 素次
Central Research Laboratories, Sankyo Co., Ltd.
-
浅井 素次
Central Research Laboratories Sankyo Co. Ltd.
-
清水 文治
Central Research Laboratories Sankyo Co. Ltd.
-
稗田 治清
Central Research Laboratories, Sankyo Co., Ltd.
-
稗田 治清
Central Research Laboratories Sankyo Co. Ltd.
関連論文
- Synthesis of 7α-Methoxy-7-[2-(substituted thio) acetamido] cephalosporin Derivatives and Their Antibacterial Activities
- N→N Alkyl and Glycosyl Migrations of Purines and Pyrimidines. IV. trans-Glycosylation from Pyrimidines to Purines. (A Novel Synthetic Method of Purine Nucleosides and Nucleotides)
- N→N Alkyl and Glycosyl Migration of Purines and Pyrimidines. III. N→N Alkyl and Glycosyl Migration of Purine Derivatives
- N→N Alkyl and Glycosyl Migration of Purines and Pyrimidines. II. Glycosyl Migration of 3-Glycosyl-N^6-acyladenine Derivatives
- N→N Alkyl and Glycosyl Migrations of Purines and Pyrimidines. I. A New Migration of 3-Alkyl-N^6-acyladenine
- Synthesis of Anomeric Pyrimidine Nucleoside 5'-Phosphates of L-Ribose, α-D-Cytidine 5'-Phosphate and 3-β-L-Ribofuranosyladenine 5'-Phosphate
- Studies on Synthetic Nucleotides. II. A Direct Synthetic Method of Ribonucleotides.
- 33 プリンおよびピリミジンヌクレオシドのグリコシル転移
- Alkyl Migration of 3-Alkylguanine Derivatives
- Intermolecular Rearrangement of N'-Acyltriacanthine
- Preparation of L-β-Ribonucleosides and L-β-Ribonucleotides
- Infrared Spectra of Pyrazine-and Pyridine-carboxylic Acid and Their Derivatives.
- Studies on Acetylenic Compounds. XXIX. A New Method for Synthesis of DL-Ribose.
- An Approach to Synthesis of Diterpenoid Alkaloids. IV.
- An Approach to Synthesis of Diterpenoid Alkaloids. III.
- An Approach to Synthesis of Diterpenoid Alkaloids. II.
- An Approach to Synthesis of Diterpenoid Alkaloids. I. Mannich Reaction of 2,6-Disubstituted Cyclohexanone.
- 23.ダイテルペンアルカロイド骨核の合成
- Synthesis of N^6- or 8-Substituted 9-(β-D-Arabinofuranosyl)-adenines and Their Antiviral Activities against Herpes Simplex and Vaccinia Viruses
- Studies on Synthetic Nucleotides. I. A Convenient Synthesis of Ribonucleotides.
- Studies on Synthetic Nucleosides V. Anomeric Pyrimidine Nucleosides of D-Arabinose and D-Lyxose
- A Convenient Synthesis of Nucleotides
- Studies on Synthetic Nucleosides. IV. A New Synthetic Method of Pyrimidine and Purine Ribosides
- A New Synthetic Method of Nucleosides
- Studies on Synthetic Nucleotides. IV. Preparation of L-β-Ribonucleosides and L-β-Ribonucleotides.
- Studies on Acetylenic Compounds. XXXVI. Total Synthesis of Ethyl 3-Amino-3-deoxy-β-DL-arabinofuranoside.
- Synthesis and Properties of 8,2'-Cyclothioguanosine and Related Compounds
- Synthesis of 9-(β-D-Arabinofuranosyl) adenine 5'-Phosphate starting from Adenosine 5'-Phosphate
- A Convenient Synthesis of 1-β-D-Arabinofuranosylcytosine
- A Convenient Synthesis of Cytosine Nucleosides
- Synthesis of D-Glucuronic Acid Derivatives of 5-Fluorouracil having O-Glycosidic Linkage
- Studies on synthetic nucleotides-1,2,4-