Quinotrierixin Inhibited ER Stress-Induced XBP1 mRNA Splicing through Inhibition of Protein Synthesis
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概要
- 論文の詳細を見る
Quinotrierixin was isolated from microbes as an inhibitor of ER stress-induced XBP1 mRNA splicing, but its mode of action was unclear. We found that quinotrierixin is an inhibitor of protein synthesis, and that the required dose range of quinotrierixin to inhibit ER stress-induced XBP1 mRNA splicing was similar to that to inhibit protein synthesis. Furthermore, we also found that quinotrierixin inhibited the ER stress-induced increases of unfolded protein response-related genes such as GRP78, CHOP, EDEM, ERdj4, and p58IPK. Thus, we showed that quinotrierixin inhibited the ER stress-induced unfolded protein response, possibly due to its inhibitory activity of protein synthesis.
- 社団法人 日本農芸化学会の論文
- 2011-02-23
著者
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IMOTO Masaya
Department of Applied Chemistry, Faculty of Science and Technology, Keio University
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Tashiro Etsu
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Imoto Masaya
Department Of Agricultural Chemistry Faculty Of Agriculture Yamaguchi University
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Imoto Masaya
Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University
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Yamamoto Kohta
Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University
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Imoto Masaya
Chemical Biology Laboratory Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University
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