Prediction of Three-Independent Scales Endowed on Poliovirus Proteinase 2A Sequence

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概要

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• Mulliken's electronegativity (M) scale was found as a parameterization to predict (elucidate) a virtually specific interaction between Poliovirus proteinase 2A and mitogen-activated protein (MAP) kinase p38α, as well as that between the 2A and apoptotic protein activating factor 1c (Apaf 1c) (or prion) with intermolecular frequency symmetry (IFS) rule. Also, Lacey's hydropathical (H) scale and Garel's (G) one could be found in the specific relationship between the 2A and the extracellular signal-regulated kinase 2 (ERK2) [or fibroblast growth factor receptor 3 (FGFR3)], and that between the 2A and the c-Jun N-terminal kinase 2 (JNK2) [or forkhead box P2-1 (FOXP2-1)], respectively. Based on these, both the same physicochemical scale and almost the same resonant frequency (f) value would be conserved in the same succession of a signal transduction process in a Poliovirus-infected cell. Furthermore, the 2A could play a trigger role to cause cancer, prion disease, bone disease, or speech and language disorder.

• 公益社団法人 日本薬学会の論文

著者

• Fukazawa Yoshiyuki

  Kanagawa Industrial Technology Center

関連論文

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• Fabrication of Shallow Silicon Nanoholes and Fixing Nanoparticles
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• Prediction of Three-Independent Scales Endowed on Poliovirus Proteinase 2A Sequence

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