The Biological Activities of Diethylstilbestrol and Its Derivatives

スポンサーリンク

概要

• 論文の詳細を見る

• Diethylstilbestol (I), a nonsteroidal estrogen, showed strong coronary vasodilator action on isolated guinea-pig heart, as well as ichthyotoxicity and antimicrobial activity. First, the coronary vasodilator action of I (ED_<50> : 0.26μg/heart) on isolated guinea-pig heart was much stronger than that of papaverine (ED_<50> : 7.0μg/heart) used as a standard. On the other hand, the activities of derivatives of I, i. e., I-diphosphate (II), I-dimethyl ether (III), I-diacetate (IV), I-dipropionate (V) and hexestrol (VI) were weaker than that of I. Second, I showed strong ichthyotoxicity (median tolerance limit at 48h : 3.30 ppm in Oryzias latipes and 4.50 ppm in Carassius auratus). On the other hand, the ichthyotoxic activities of II-V were weaker than that of I. However, VI showed the same toxicity as I on both fishes. Third, the antimicrobial activities of II-V were weaker than that of I, whereas that of VI was stronger. In particular, I and VI showed strong antifungal activity against Trichophyton spp. It was concluded that both the hydroxyl groups attached to the benzene rings and the transolefin structure are necessary for coronary vasodilator action, while only the hydroxyl groups attached to the benzene ring are necessary for the ichthyotoxic and antimicrobial activities.

• 社団法人日本薬学会の論文
• 1985-10-25

著者

• 小澤 貢

  大阪薬大

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 馬場 きみ江

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 小澤 貢

  Osaka University of Pharmaceutical Sciences

• 小川 雅史

  Osaka University Of Pharmaceutical Sciences

• 久保 真百合

  Osaka University of Pharmaceutical Sciences

• 森脇 将光

  Osaka College of Pharmacy

• 辻坊 裕

  大阪薬大

関連論文

• 64 Daphne genkwaより得られる新ビフラボノイド類の構造(ポスター発表の部)
• Antibacterial Activity of Two Chalcones, Xanthoangelol and 4-Hydroxyderricin, Isolated from the Root of Angelica keiskei KOIDZUMI
• ジンチョウゲ科植物成分の化学的研究(第4報)芫花根の新スビロビフラボノイドGenkwanol Aの構造
• 藻類およびコケ培養細胞に対する rhodanine と 2(5H)-thiophenone の効果
• Phytogrowth-Inhibitory Activities of 2-Thiophenecarboxylic Acid and Its Related Compounds
• Phytogrowth-Inhibitory Activities of Sulfur-Containing Compounds. II.The Inhibitory Activities of Thiosalicylic Acid and Dihydro-2(3H)-thiophenone-Related Compounds on Plant Growth
• Phytogrowth-Inhibitory Activity of Sulphur-Containing Compounds. I. Inhibitory Activities of Thiazolidine Derivatives on Plant Growth
• Relationship between Structure and Phytogrowth-Inhibitory Activity of 2,5-Dihydroxy-1,4-dithiane-Related Compounds
• Structure-Activity Relationship of 3,3'-Dihydroxy-α, β-diethyldiphenylethane and Its Related Compounds
• Inhibitory Effects of 3,3', 4,5'-Tetrahydroxystilbene and 3,3', 4,5'-Tetrahydroxybibenzyl, the Constituents of Cassia garrettiana on Antigen-Induced Histamine Release in Vitro
• THE INHIBITORY EFFECT OF 3,3', 4,5'-TETRAHYDROXYSTILBENE, A CONSTITUENT OF CASSIA GARRETTIANA, ON ANTI-IgE-INDUCED HISTAMINE RELEASE FROM HUMAN BASOPHILS IN VITRO
• Phytogrowth-Inhibitory and Antimicrobial Activities of 3,4'-Dihydroxy-α, β-diethylstilbene, the Isomer of Diethylstilbestrol
• Hypotensive Effects on Spontaneously Hypertensive Rats and Antifungal Activity on Various Species of Fusarium oxysporum of Diethylstilbestrol-Related Compounds
• The Hypotensive Effect and Antifungal Activity of 3,3'-Dihydroxy-α, β-diethyldiphenylethane
• Antifungal Activity against Plant-Pathogenic Fungi and Phytogrowth-Inhibitory Activity of 3,3'-Dihydroxy-α, β-diethyldiphenylethane
• Biological Actibities of Hexesterol
• THE ICHTHYOTOXICITY AND CORONARY VASODILATOR ACTION OF 3,3'-DIHYDROXY-α,β-DIETHYLSTILBENE(Communications to the Editor)
• The Biological Activities of Podophyllotoxin Compounds
• The Biological Activities of Diethylstilbestrol and Its Derivatives
• THE ICHTHYOTOXICITY AND CORONARY VASODILATOR ACTION OF DIETHYLSTILBESTROL
• Novel Hypotensive Peptides from the Body of Elaphe climacophora
• Antimicrobial Activity on Plant-Pathogenic Microorganisms and Phytogrowth-Inhibitory Activity of Streptothricin Antibiotics, Racemomycin-A and -C
• モノテルペンの生物学的特性 モノテルペンのラットに対する血圧降下作用と植物病原真菌に対する抗真菌効果
• Phytogrowth-Inhibitory Activities of Tropolone and Hinokitiol
• 写真処理廃液中に含まれるEDTA鉄キレート分解菌株A-1の特性
• EDTA鉄キレート分解菌(B-3)の特性について
• Determination of β-Lactam Antibiotics in Water by Fluorescence Quenching of Mercurochrome, and Application for Simple Investigation of Potency
• Study on Conformations-Biological Activities Relationships for Podophyllotoxin Analogues Based on Crystal Structure of Deoxypodophyllotoxin (Anthricin)
• Studies on the Constituents of the Water Extract of the Root of Mulberry Tree (Morus bombycis KOIDZ)
• Structure and Absolute Configuration of Sargatriol, a New Isoprenoid Chromenol from a Brown Alga, Sargassum tortile C. AGARDH
• Pseudoalteromonas sp. O-7株のキチン分解系に関与するプロテアーゼに関する研究
• 海洋細菌Altermonas sp. 0-7株由来キチナーゼ(ChiC)のドメインの発現およびその機能 : 酵素
• 好熱性放線菌Streptomyces thermoviolaceus OPC-520株のキシラナーゼ遺伝子のクローニングおよび発現 : 酵素
• Coumarins from the Roots of Angelica laxiflora DIELS
• The Biological Actions of Deoxypodophyllotoxin (Anthricin). I. Physiological Activities and Conformational Analysis of Deoxypodophyllotoxin
• Cytotoxic Effect of Hinokitiol and Tropolone on the Growth of Mammalian Cells and on Blastogenesis of Mouse Splenic T Cells
• Isolation of Cytotoxic Substance, Kalafungin from an Alkalophilic Actinomycete, Nocardiopsis dassonvillei subsp. presina
• New Ester Coumarins, Angeladin and Isoedultin from Angelica longeradiata (MAXIM.) KITAGAWA
• Effects of 3,3'-dihydroxy-α, β-diethylstilbene and 3,3', 4,5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks
• Toxicological Approaches to Streptothricin Antibiotics. IV. Toxicity of Streptothricin Antibiotics to the Blood
• Components of the Root of Anthriscus sylvestris HOFFM. II. Insecticidal Activity
• Physiological Activity of Streptothricin Antibiotics
• 海洋細菌Alteromonas sp. 0-7株のキチナーゼ遺伝子のクローニングおよび大腸菌での発現 : 酵素
• 海洋細菌Alteromonas sp. O-7株由来クローン化セリンプロテアーゼ(Aprl)の精製およびその諸性質 : 酵素
• Changes of Tissue Histopathology and Uric Acid Excretion in Silkworm Larvae Intoxicated with Deoxypodophyllotoxin and Racemomycin-D, and during Starvation
• Mechanisms of Inhibitory Action of Racemomycin-D on Plant Growth
• The Biological Activities of 3,4-O-Isopropylidene-3,3'4,5'-tetrahydroxystilbene
• 3,3', 4,5'-Tetrahydroxystilbeneならびにその誘導体の冠血管拡張ならびに血圧降下作用
• Mechanisms of Insecticidal Action of Deoxypodophyllotoxin (Anthricin). II. Histopathological Studies on Tissues of Silkworm Larvae Intoxicated by Deoxypodophyllotoxin
• THE ANTIFUNGAL ACTIVITY OF STILBENE DERIVATIVE
• Physiological Activities of 3,3', 4,5'-Tetrahydroxystilbene Isolated from the Heartwood of Cassia garrettiana CRAIB.
• Studies on Metabolites Produced by Aspergillus terreus var. aureus. I. Chemical Structures and Antimicrobial Activities of Metabolites Isolated from Culture Broth
• Mechanisms of Insecticidal Action of Deoxypodophyllotoxin (Anthricin). I. Distribution of Deoxypodophyllotoxin in Tissues of the 5th Instar Larvae of Silkworm, Bombyx mori LINNE
• The Mechanisms of Delayed Insecticidal Action of Streptothricin Antibiotics. I. Toxic Symptoms and Distribution of Racemomycin-D into the Tissues of the 5th Instar Larvae of Silkworm, Bombyx mori LINNE
• The Mechanisms of Delayed Insecticidal Action of Streptothricin Antibiotics. II. Effect of Racemomycin-D on Excretion Function of the 5th Instar Larvae of Silkworm, Bombyx mori LINNE
• Insecticidal Activity of Streptothricin Antibiotics
• 67 Streptothricin抗生物質の生合成に関する研究
• Biological Activities of Racemomycin-B, β-Lysine Rich Streptothricin Antibiotic, the Main Component of Streptomyces lavendulae OP-2
• Effects of Stilbene Components of the Roots of Polygonum cuspidatum SIEB. et ZUCC. on Lipid Metabolism
• Phytogrowth-Inhibitory and Antibacterial Activities of 2,5-Dihydroxy-1,4-dithiane and Its Derivatives
• EFFECT OF 3,3'-DIHYDROXY-α, β-DIETHYLDIPHENYLETHANE ON CORONARY AND MESENTERIC ARTERIES ISOLATED FROM GUINEA-PIGS
• Biological Actions of the Natural Coumarins. I. Changes of Lipids and Glucose Levels in Rat Plasma after Intraperitoneal Administration of Various Linear-Type Furanocoumarins
• Coumarins from the Roots of Angelica morii HAYATA
• Stability of Enzyme Preparations on Radiosterilization
• Biosynthesis of Streptothricin Antibiotics. III. Incorporation of D-Glucosamine into D-Gulosamine Moiety of Racemomycin-A
• Hypotensive Compounds Isolated from the Dried Body of Naja naja Kaouthia LESSON. I. : Isolation of Inosine as a HYpotensive Principle and Structure-Activity Study of Related Compounds
• Chemical Studies on the Heartwood of Cassia garrettiana CRAIB. III. : Structures of Two New Polyphenolic Compounds
• 88(PA3-8) ジンチョウゲより得られる新ビフラボノイド類の構造(ポスター発表の部)
• Chemical Studies on the Constituents of the Thymelaeaceous Plants. III. Structure of a Novel Spiro Biflavonoid, Daphnodorin C, from Daphne odora THUNB.(Organic,Chemical)
• STRUCTURE OF A NEW POLYPHENOL FROM CASSIA GARRETTIANA CRAIB.
• THE REVISED STRUCTURE OF DAPHNODORIN C, A NOVEL SPIRO BIFLAVONOID
• Chemical Studies on the Constituents of the Thymelaeaceous Plants. II. : Stereochemistry of Daphnodorin A and Daphnodorin B
• Hypotensive Compounds Isolated from Alcohol Extract of the Unossified Horn of Cervus elaphus L. var. xanthopygus MILNE-EDWARG (Rokujo). I. Isolation of Lysophosphatidyl Choline as a Hypotensive Principle and Structure-Activity Study of Related Compounds(P
• CHEMICAL STRUCTURE OF A NEW METABOLITE ISOLATED FROM THE MYCELIUM OF ASPERGILLUS TERREUS VAR. AUREUS
• Mechanism of Insecticidal Action of Deoxypodophyllotoxin(Anthricin). III. : The Mode of Delayed Insecticidal Action of Deoxypodophyllotoxin
• The Mechanisms of Delayed Insecticidal Action of Streptothricin Antibiotics. III. The Mode of Delayed Insecticidal Action of Racemomycin-A(Biological)
• Structure of Anthriscusin, a New Phenylpropanoid Ester from the Roots of Anthriscus sylvestris HOFFM.
• ジンチョウゲ科植物成分の化学的研究(第5報)ジンチョウゲの根から得かれる新ビフラボノイドDaphnodorin Dの構造
• 超臨界流体抽出の生薬, 植物成分への応用(第1報)蛇床子成分の抽出に及ぼす圧力, 温度, 時間, エントレーナーの影響
• Chemical Studies on the Constituents of the Thymelaeaceous Plants. I. : Structures of Two New Flavans from Daphne odora THUNB.
• Chemical Studies of Angelica japonica A. GRAY. I. On the Constituents of the Ethyl Acetate Extract of the Root
• Coumarins and a Sesquiterpene from the Crude Drug "Korean Qianghuo (韓国羌活)," the Roots of Angelica spp.
• The Structures of Yellow Pigments from the Rhizomes of Cimicifuga dahurica MAXIM.
• Studies on Coumarins from the Root of Angelica pubescens MAXIM. III. Structures of Various Coumarins including Angelin, a New Prenylcoumarin
• Chemical Studies on the Heartwood of Cassia garrettiana CRAIB. II. Nonanthraquinonic Constituents
• Chemical Studies on the Heartwood of Cassia garrettiana CRAIB. I. Anthraquinones including Cassialoin, a New Anthrone C-Glycoside
• The Structure of Yellow Pigment from the Rhizomes of Cimicifuga dahurica MAXIM.
• The Structure of Xanthoangelol, a New Chalcone from the Roots of Angelica keiskei KOIDZUMI (Umbelliferae)
• The Structure of Cassialoin, a New Anthrone C-Glycoside from the Heartwood of Cassia garrettiana CRAIB.
• Neue Xanthon Glykosid, Dillanosid, aus Dill, die Frucht der Anethum graveolens L.
• Uber die Cumarine der Boenninghausenia japonica (SIEB.) NAKAI
• THREE NEW FLAVANS FROM THE ROOT OF DAPHNE ODORA THUNB.
• 中国産防風の研究(III) : 水防風の成分について
• アシタバの成分(第5報) : 果実の成分および果実,根,葉におけるクマリン類,カルコン類の比較
• 中国産防風の研究(II) : クマリン類,クロモン類,ポリアセチレン類による防風類の比較
• 生薬資源の研究(第8報) : 生薬「何首鳥」中の2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucosideの分布と公定試験法について
• Chemical Studies on the Constituents of the Chinese Crude Drug "Quiang Huo"
• Chemical Studies of Coelopleurum gmelinii (D.C.) LEDEB. I. Constituents of the Root
• Studies on Coumarins from the Root of Angelica pubescens MAXIM. V. Stereochemistry of Angelols A-H
• Studies on Coumarins from the Root of Angelica pubescens MAXIM. IV. Structures of Angelol-Type Prenylcoumarins

もっと見る 閉じる

スポンサーリンク