Physiological Activity of Streptothricin Antibiotics
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概要
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The physiological activities of streptothricin antibiotics were investigated, taking racemomycin-D as a representative of the group. It was found that racemomycin-D has insecticidal activity, fish-toxicity and inhibitory activity on plant growth. Firstly, racemomycin-D showed a weak but broad-spectrum insecticidal activity against the adults of Blattella germanica, Musca domestica, Nilaparvata lugens, Laodelphax striatella, and Plutella xylostella. A rather strong insecticidal effect on Culex pipiens molestus larvae was found, with mortalities of 90% and 15% at 10 ppm and 2 ppm, respectively. Though racemomycin-D showed no insecticidal effect against the larvae of Spodoptera litura, it showed inhibitory activity on feeding at a concentration of 300 ppm. Secondly, racemomycin-D was toxic to all the fish species examined, i. e., Misgurnus anguillicaudatus, Carassius auratus, and Oriziae latipes. Among these, racemomycin-D showed particularly strong toxicity against C. auratus with a TLm of 3.7 ppm (after 48 hr). Thirdly, racemomycin-D showed strong inhibitory activity on the growth of Brassica campestris L. subsp. Napus Hook fil et Anders var. nippo-okifera, Arctium Lappa L., Petrocelium sativum, and Raphanus sativus L. var. acanthiformis at a concentration of 500 ppm (with an inhibitory ratio of 0.1,relative to 1.0 for the control group).
- 社団法人日本薬学会の論文
- 1980-10-25
著者
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加藤 喜昭
Osaka University Of Pharmaceutical Sciences
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竹本 常松
Pharmaceutical Institute, Tohoku University
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久保 真百合
Osaka University of Pharmaceutical Sciences
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森本 一洋
大阪薬科大学第2薬剤学教室
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森本 一洋
大阪薬科大学 薬剤学教室
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
Faculty Of Pharmaceutical Sciences Nagasaki University
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森坂 勝昭
Osaka University of Pharmaceutical Sciences
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竹本 常松
Pharmaceutical Faculty Tokushima Bunri University
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坂井 道彦
Takeda Chemical Industries
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竹本 常松
徳島文理大 薬
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坂井 道彦
Takeda Chemical Industries Ltd.
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