Stereoselective Epoxidation of Germacradienes by Enzymes and Selective Transannular Cyclization of Germacradienes and Their Epoxides
スポンサーリンク
概要
- 論文の詳細を見る
Microbial transformation of germacrone (5) using Cunninghamella blakesleeana has resulted in the stereoselective attack of oxidation enzymes to give three optically active epoxides (6,7,and 8) whose stereostructures have been elucidated by chemical and physicochemical evidence. Transannular cyclization of germacrone 1,10-epoxide (6) and germacrone 4,5-epoxide (7) by acids has been performed and it has been found that the former gives the eudesmanes (10 and 11) while the latter affords the guaianes (9 and 12-15). The mechanism of acid-induced transannular rearrangement of germacra-1 (10), 4-dienes and their epoxides is discussed.
- 公益社団法人日本薬学会の論文
- 1977-01-25
著者
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竹本 常松
Pharmaceutical Institute, Tohoku University
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今野 長八
Pharmaceutical Institute Tohoku University
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ヒキノ ヒロシ
Pharmaceutical Institute Tohoku University
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ヒキノ ヒロシ
東北大学薬学部
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ヒキノ ヒロシ
Pharmaceutical Institute Faculty Of Medicine Tohoku University
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ヒキノ ヒロシ
東北大薬
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竹本 常松
Pharmaceutical Faculty Tokushima Bunri University
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永島 利美
Pharmaceutical Institute, Tohoku University
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小浜 友昭
Pharmaceutical Institute, Tohoku University
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竹本 常松
Institute of Pharmacognosy, Tokushima Bunri University
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竹本 常松
Institute Of Pharmacognosy Tokushima Bunri University
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小浜 友昭
Pharmaceutical Institute Tohoku University
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永島 利美
Pharmaceutical Institute Tohoku University
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