Stereoselectivity in Microbiological Transformation of Stereoisomers of α-Cyperone and Dihydro-α-cyperone with Colletotrichum phomoides

概要

論文の詳細を見る
Incubation of three stereoisomers of α-cyperone (1,2,and 3) with Colletotrichum phomoides resulted in two types of modification hydroxylation (C-2 and C-6) in one isomer (2) and dehydrogenation (C-6 : C-7) in another isomer (3) at the nuclei and in three types of modification (hydration to an alcohol, allylic hydroxylation to an allyl alcohol, and oxidation to a 1,2-glycol) at the side chains in all the isomers in different rates. On fermentation with the same microbe of three stereoisomers of dihydro-α-cyperone (16,17,and 18), prepared for prevention of the side chain modification, hydroxylation at the nucleus (C-1) occurred merely in one isomer (16), and the same types of oxidation at the side chains also took place in all the isomers as in their congeners (1-3). The stereoselectivity and the probable mechanisms of the transformations are discussed.
公益社団法人日本薬学会の論文
1975-06-25