Synthesis of Cyperene, Cyperotundone, and Patchoulenone
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概要
- 論文の詳細を見る
Isopatchoul-9-en-5α-ol (VII) was hydrogenated using nickel catalyst in methanol to give 10α (H)-isopatchoulan-5α-ol (XII). Dehydration of the alcohol (XII) formed 10-epi-cyperene (IV) which on oxidation yielded 10-epi-cyperotundone (V). The alcohol (VII) was converted into 9α-acetoxy-10α (H)-isopatchoul-4-ene (XVII) via 10α (H)-isopatchoulane-5α, 9α-diol (XIV) by known methods. Hydrolysis of the unsaturated acetate (XVII) afforded 10α (H)-isopatchoul-4-en-9α-ol (XIX) which was oxidized to yield isopatchoul-4-en-9-one (XXI). Wolff-Kishner reduction of the ketone (XXI) furnished cyperene (III) which on oxidation gave cyperotundone (I) and patchoulenone (II).
- 社団法人日本薬学会の論文
- 1968-01-25
著者
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竹本 常松
Pharmaceutical Institute, Tohoku University
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青田 恵太郎
東北大学薬学部
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ヒキノ ヒロシ
Pharmaceutical Institute Tohoku University
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ヒキノ ヒロシ
Pharmaceutical Institute Faculty Of Medicine Tohoku University
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伊藤 邦雄
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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青田 恵太郎
Pharmaceutical Institute, Tohoku University School of Medicine
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竹本 常松
Pharmaceutical Faculty Tokushima Bunri University
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伊藤 邦雄
Pharmaceutical Institute Tohoku University
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