Absorption, Distribution, Metabolism, and Excretion of Insect-Metamorphosing Hormone Ecdysterone in Mice. II
スポンサーリンク
概要
- 論文の詳細を見る
The absorption, distribution, and excretion of ^3H-labelled ecdysterone were studied in mice by means of autoradiographic technique. When administered intraperitoneally, ecdysterone was rapidly and easily absorbed into the blood and distributed to various organs (in particular, in the excretory organs such as the liver, gall bladder, intestine, and kidney) in which the radioactivity reached the maximal levels quite soon. Its clearance from the organs excluding the excretory organs was rather rapid, and the radioactivity specifically accumulated in the liver was gradually transported into the intestinal lumen via the gall bladder which showed the highest and continuous uptake. The glandular secretion of radioactivity into the gastric mucosa also partially contributes to its transportation from the blood to the digestive tract. After oral administration of ^3H-ecdysterone, the absorption from the intestine was slow and limited and high radioactivity in the gastrointestinal tract was retained. The liver took up some radioactivity which attained a maximum soon after administration and gradually decreased due to the biliary excretion through the gall bladder in which the radioactivity hit the maximum level about 1 hr after administration and maintained a high level thereafter. Elimination of the administered ecdysterone from the body appears to be fast and its excretion pattern indicates that the excretion in the feces, mostly derived from the biliary excretion, is much more important than that in the urine after both intraperitoneal and oral administration.
- 社団法人日本薬学会の論文
- 1972-11-25
著者
-
大泉 康
Pharmaceutical Institute, Tohoku University
-
竹本 常松
Pharmaceutical Institute, Tohoku University
-
大泉 康
東北大学薬学部
-
ヒキノ ヒロシ
Pharmaceutical Institute Tohoku University
-
ヒキノ ヒロシ
東北大学薬学部
-
ヒキノ ヒロシ
Pharmaceutical Institute Faculty Of Medicine Tohoku University
-
ヒキノ ヒロシ
東北大薬
-
大泉 康
Pharmaceutical Institute Tohoku University
-
竹本 常松
Pharmaceutical Faculty Tokushima Bunri University
-
竹本 常松
Institute of Pharmacognosy, Tokushima Bunri University
-
竹本 常松
Institute Of Pharmacognosy Tokushima Bunri University
関連論文
- PRIMARY STRUCTURE OF THE LECTIN FROM THE VENOM OF BITIS ARIETANS (PUFF-ADDER)
- Microbiological Transformation of (-)-Kaur-16-en-19-oic Acid
- A Revised Structure of Tomatillidine
- Studies on the Constituents of Chloranthus spp. II. The Sesquiterpenes from Chloranthus serratus
- Studies on the Constituents of Chloranthus spp. I. The Structures of Two New Amides from Chloranthus serratus and the Isolation of Isofraxidin from C. japonicus
- Stimulatory Effect of Insect-Metamorphosing Steroids from Ferns on Protein Synthesis in Mouse Liver
- Stimulation of Protein Synthesis in Mouse Liver by Insect-Moulting Steroids
- Structure and Absolute Configuration of Cyperolone.
- Structure of Cyperolone
- Shidasterone, an Insect Metamorphosing Substance from Blechnum niponicum : Structure
- Studies on the Constituents of the Water Extract of the Root of Mulberry Tree (Morus bombycis KOIDZ)
- Long-range Effect of Halogen in the Nuclear Magnetic Resonance Spectra of Halosteroids
- Structure and Absolute Configuration of Kobusone and Isokobusone
- Structure and Absolute Configuration of Sugetriol
- Biochemical Syntheses. II. Microbial Transformation of Cyperotundone to Sugeonol and Isopatchoul-4-en-3-on-8α-ol
- Structure and Absolute Configuration of Sugeonol
- Synthesis of Cyperene, Cyperotundone, and Patchoulenone
- Structure and Absolute Configuration of Cyperol and Isocyperol.
- Structure of Sugetriol
- Structure and Absolute Configuration of Cyperotundone
- Structure of Cyperotundone
- 筋収縮系の生化学的研究に有用な天然生理活性物質
- Stereostructure of Rhodojapoin V and VII, Toxins of Rhododendron japonicum
- Stereostructure of Picrasin G, Simaroubolide of Picrasma quassioides
- Stereostructure of Picrasin C, Simaroubolide of Picrasma quassioides
- Stereostructure of Picrasin F, Simaroubolide of Picrasma quassioides
- Stereostructure of Grayanotoxin VIII, IX, X, and XI. Toxins of Leucothoe grayana
- Stereostructure of Picrasin D and E, Simaroubolides of Picrasma quassioides
- Stereostructure of Rhodojaponin IV, Toxin of Rhododendron japonicum, and of Grayanotoxin V, VI, and VII, Toxins of Leucothoe grayana
- Stereostructure of Picrasin B, Simaroubolide of Picrasmaquassioides
- Stereostructure of Rhodojaponin I, II, and III, Toxins of Rhododendron japonicum, and of Asebotoxin III, Toxin of Pieris japonica
- Constituents of Chondria armata
- Components of the Root of Anthriscus sylvestris HOFFM. II. Insecticidal Activity
- Physiological Activity of Streptothricin Antibiotics
- 応用薬理研究会のこれまでの40年とこれからの40年
- グリア細胞におけるトロンボキサンA_2受容体情報伝達系
- 31B-05 麻黄附子細辛湯のグリア細胞に対する作用の解析
- トロンボキサンA_2受容体サブクラスと新しい情報伝達系
- I-C-9 葛根湯, 小柴胡湯および麻黄湯のウサギ培養アストロサイトにおけるプロスタグランジン生成およびイノシトールリン脂質水解への作用
- Isolation of Phytoecdysones from Japanese Ferns. I
- Stereostructure of Lyoniatoxin, Toxin of Lyonia ovalifolia var. elliptica
- Isolation of Insect-Moulting Substances from Blechnum amabile and Blechnum niponicum
- Structure and Absolute Configuration of Faurinone
- Isolation of Insect Moulting Substances from Osmunda japonica and Osmunda asiatica
- Isolation of Insect Moulting Substances from Pteridium aquilinum var. latiusculum
- Isolation of Insect Moulting Substances from Pleopeltis thunbergiana, Neocheiropteris ensata, and Lemmaphyllum microphyllum
- Isolation of Insect Moulting Substances from Matteuccia struthiopteris, Lastrea thelypteris, and Onoclea sensibilis
- 学術貢献賞受賞高柳一成氏の業績
- 21世紀の創薬のための海洋資源(21世紀の創薬資源)
- Subchronic Toxicity of Ericaceous Toxins and Rhododendron Leaves
- 附子の薬理作用
- 附子の修治に伴うアルカロイド組成と急性毒性の変化
- Absorption, Distribution, Metabolism, and Excretion of Insect-Metamorphosing Hormone Ecdysterone in Mice. II
- 昆虫変態ホルモンエクジステロンのマウスにおける吸収, 分布, 代謝および排泄その1
- Effects of a Vertebrate Hypocholesterolemic Agent on Sterol Metabolism and Development of Bombyx mori
- Antidepressant Principles of Valeriana fauriei Roots
- 51 ブドウ科植物の薬理活性成分研究 : 肝障害および肝障害予防作用を有するオリゴスチルベン(口頭発表の部)
- Stereostructure of Asebotoxin VI, VIII, and IX, Toxins of Pieris japonica
- Stereoselective Epoxidation of Germacradienes by Enzymes and Selective Transannular Cyclization of Germacradienes and Their Epoxides
- Stereoselectivity in Microbiological Transformation of Stereoisomers of α-Cyperone and Dihydro-α-cyperone with Colletotrichum phomoides
- Carbon-13 Nuclear Magnetic Resonance Spectra of Phytoecdysones
- Structure of Dehydrocurdione, a Sesquiterpenoid of Curcuma zedoaria
- Structure of Curcumadiol, a Sesquiterpenoid of Curcuma zedoaria
- Studies on Constituents of Iris Genus Plants. III. The Constituents of Iris florentina L. (1)
- Stereostructure of Asebotoxin VII, Toxin of Pieris japonica
- Stereostructure of Asebotoxin IV and V, Toxins of Pieris japonica
- Stereochemistry of Grayanotoxins, Asebotoxins, and Rhodojaponins, Toxins of Ericaceae
- Screening of Formosan Ferns for Phytoecdysones. I
- Screening of Japanese Ferns for Phytoecdysones. I
- 海綿由来の新規SH基修飾薬Xestoquinoneによる筋収縮機構の解析
- 循環器疾患におけるアシドーシスの役割
- アンチセンスオリゴDNAを用いた細胞膜カルシウムポンプ活性の選択的抑制
- 生活活性物質をツールとして用いた細胞情報伝達機構の解明と創薬
- 天然生理活性物質の創薬科学への応用
- Structure of Pteroside A and C, Glycosides of Pteridium aquilinum var. latiusculum
- Structure of Pteroside Z and D, Glycosides of Pteridium aquilinum var. latiusculum
- Structure of Pteroside B, Glycoside of Pteridium aquilinum var. latiusculum
- クワの葉より昆虫変態ホルモンの単離
- 牛膝より昆虫変態ホルモンの単離
- Spasmolytic Substances from Cimicifuga dahurica MAXIM.
- Selective Chemical Alkylation of Nucleotides with Triethyloxonium Fluoroborate
- A Photoreductive Removal of the Toluene-p-sulfonyl Group
- Stereostructure of Picrasin A, Simaroubolide of Picrasma quassioides
- The Constituents of Iris florentina L. (3). Structure of Irisxanthone, a New C-Glycosylxanthone
- Studies on Constituents of Iris Genus Plants. IV. The Constituents of Iris florentina L. (2)
- Fusidic Acid, a Steroidal Antibiotic from Isaria kogane
- Structure of β-Kessyl Ketone and β-Kessyl Alcochol
- Structure of Zederone
- Structure of Curdione
- Structure of Curdione
- Structure of Zederone
- Proton Magnetic Resonance Study of Some 17-Substituted Steroids
- Structure and Absolute Configuration of Campherenone and Campherenol, Sesquiterpenoids of Cinnamomum camphora
- Structure and Absolute Configuration of Kusunol
- Synthesis of Cyperolone and 3-epi-Cyperolone.
- Synthesis of Cyperolone
- Application of the Infinite Dilution Shifts in Acid-Base System to Organic Chemistry. I.Relation between the Infinite Dilution Shifts of Monosubstituted Benzoic Acids in Pyridine and the Hammett δ Values
- Structure of Isocyasterone and Epicyasterone, Novel C_ Insect-Moulting Substances from Cyathula capitata
- Absolute Configuration of Cyasterone, An Insect-Moulting Substance from Cyathula capitata
- Structure of Precyasterone, A Novel C_ Insect-Moulting Substance from Cyathula capitata