51 ブドウ科植物の薬理活性成分研究 : 肝障害および肝障害予防作用を有するオリゴスチルベン(口頭発表の部)

概要

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Some of Vitaceaeous plants have been used as anti-inflammatory in the treatment of liver diseases. In our continuous effort to discover anti-hepatotoxic constituents from Oriental medicinal plants, we observed that methanol extract of Vitis coignetiae exhibited strong inhibition against cytotoxicity induced by several hepatotoxic drugs using primary cultured rat hepatocytes. Further, ethyl acetate solubles of the methanol extract were also anti-hepatotoxic in the assay. Fractionation of the solubles led to the isolation of a new stilbene oxidative dimer, ε-viniferin diol (1), and two new stilbene oxidative tetramers, vitisins A (3) and B (8). Vitisins A (3) and B (8) were isolated as mixtures with their stereoisomers,4 and 9, respectively. Their structures were elucidated on the basis of extensive spectroscopic analyses, especially by the combination of 2D NMR methods such as HMBC experiment, as well as some reactions. Evaluation of the oligostilbenes isolated from Vitaceaeous plants was caried out. Thus, treatment of mice with ε-viniferin (2) has been found to strongly inhibit the increase of GPT value after carbon tetrachloride injection. While vitisin A (3) and ampelopsin C (11) produced severe damage in the mice liver. These observations were confirmed by histological investigation.
天然有機化合物討論会の論文
1991-09-07