71(P45) Dictyosterium属細胞性粘菌の成分(ポスター発表の部)

概要

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Slime molds have attracted attention as phylogenetically interesting organisms that have characteristics for both plants and animals in thire unique life cycle. Amoebae, appeared by germination of spores, consume bacteria by phagocytosis and multiply by division. Starvation causes the amoebae to aggregate with signal of cyclic AMP, and it differentiates into two types of cells, stalk cells and spore cells, to form fruit bodies. Slime molds are classified into two classes, Myxomycetae and Acrasiomycetae. The latter is called cellular slime molds, and used as a model of embryology and differentiation in biology because its cultivation method has been established. But, as for thire metabolites, only DIF-1, a differentiation factor of slime molds, and a few compounds have been reported. In this study, we focused on the secondary metabolites of slime molds, and isolated seven novel compounds from Dictyosterium sp. Dibenzofuran compounds D-1 (1) and D-2 (2) were isolated from D. medium. D-3 (3) and D-4 (4), bearing α-pyron moiety, and phosphatidyl lipids D-5 (5) and D-6 (6)with unique fatty acid were isolated from D. discoideum. Moreover, norditerpenoid D-7 (7) was obtained from D. purpreum. These structures were elucidated by the spectroscopic and chemical methods. The absolute configurations of D-3 (3) and D-4 (4) were determined by the comparison of their CD spectra with that of a known compound.
1998-08-31