P-37 未利用微生物・細胞性粘菌が産生する生物活性物質(ポスター発表の部)

概要

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Cellular slime molds are thought to be excellent model organisms for the study of cell and developmental biology because of their simple pattern of development. However, there have been no reports on secondary metabolites of them. We have focused on the utility of cellular slime molds as novel resources for natural product chemistry, and have studied the diversity of secondary metabolites produced by them as well as their physiological and pharmacological activities. In this study, we show the isolation of five novel secondary metabolites Pt-1〜5 (1-5), which are prenylated or geranylated aromatic compounds, from cellular slime mold Polysphondylium tenuissimum. The structures of 1-5 were determined by spectral means including EIMS, and ^1H and ^<13>C NMR. In addition, we synthesized DIF-1 (6), a stalk-cell differentiation inducer in cellular slime mold Dictyostelium discoideum, and its analogs. DIF-1 (6) also exhibited anti-proliferative activities and induced cell differentiation in mammalian cells. We evaluated their biological activities to assess structure-activity relationship of them and to develop useful compounds for the study of both Dictyostelium development and cancer biology.
天然有機化合物討論会の論文
2008-09-01