P-51 新規天然資源細胞性粘菌の二次代謝産物とその生物活性(ポスター発表の部)

概要

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Cellular slime molds are thought to be excellent model organisms for the study of cell and developmental biology because of their simple pattern of development. However, there have been no reports on secondary metabolites of them. We have focused on the utility of cellular slime molds as novel resources for natural product chemistry, and have studied the diversity of secondary metabolites produced by them as well as their physiological and pharmacological activities. We have recently isolated α-pyronoids, named dictyopyrones A-D (1-4), from various species of Dictyostelium cellular slime molds, and it was shown that compound 3 may regulate Dictyostelium development. In this study, we synthesized dictyopyrone A-D (1-4) and their analogues, investigated the physiological role of the molecules in cell growth and morphogenesis in D. discoideum, and further verified their effects on human leukemia K562 cells. In addition, novel dictyopyrone analogs, dihydrodictyopyrone A (5) and C (6), and a novel aromatic amide, brefelamide (7), were isolated from methanol extracts of the fruiting bodies of Dictyostelium cellular slime molds. The structures of 5-7 were determined by spectral means including EIMS, and ^1H and ^<13>C NMR. The total synthesis of 7 was also carried out to confirm the structure and obtain sufficient samples for performing biological evaluation.
天然有機化合物討論会の論文
2005-09-15