58(P-27) 冬虫夏草Paecilomyces tenuipesより得られた新規トリコテカンの構造と生物活性(ポスター発表の部)

概要

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Paecilomyces tenuipes, which was also called Isaria japonica, is one of the famous entomopathogenic fungi. This fungus is used as a treatment of various diseases and an activator of physiological functions in Chinese from ancient times. It is very rare and expensive because of difficulty of its collection in the nature. We cultivated fruit body of Paecilomyces tenuipes on a large scale, and isolated four novel highly oxygenated trichothecanes 1-4 from the methanol extract of it.. 1 and 2 are the first example of trichothecanes which possess a spiro ring. 1-3 showed moderate neuronal differentiation activity on PC-12 cells. It is interesting that the production of trichothecanes was dependent on culture conditions. Some trichothecanes are famous as mycotoxins, therefore, the isolation of this type of compounds suggested that artificially cultivated fruit body of Paecilomyces tenuipes should be carefully used as medicines and medicinal health food.
2002-09-01