Antibacterial Activity of Two Chalcones, Xanthoangelol and 4-Hydroxyderricin, Isolated from the Root of Angelica keiskei KOIDZUMI

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概要

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• Two chalcones, xanthoangelol (I) and 4-hydroxyderricin (II), isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae) showed antibacterial activity against gram-positive pathogenic bacteria. The activity of I on Micrococcus luteus IFO-12708 (minimum inhibitory concentration (MIC), 0.76 μg/ml) was the same potency as that of gentamicin, which is used as a standard. Although the activity of both chalcones on plant-pathogenic bacteria was lower than that of streptomycin sulfate, used as a positive control, they also exhibited growth-inhibitory effects. The antibacterial activity of I isolated from Angelica keiskei KOIDZUMI is being reported here for the first time. The growth-inhibitory effect of II on plant-pathogenic bacteria is also reported for the first time in this paper.

• 社団法人日本薬学会の論文
• 1991-06-25

著者

• 谷口 雅彦

  大阪薬科大学薬学部

• 小澤 貢

  大阪薬大

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 馬場 きみ江

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 谷口 雅彦

  Osaka University of Pharmaceutical Sciences

• 中田 功二

  Osaka University of Pharmaceutical Sciences

• 小澤 貢

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  大阪薬大

• 中田 功二

  大阪薬科大学

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