63(P35) 雲南羌活(Pleurospermum rivulorum)より得られる新ビクマリンおよび新トリクマリン類の構造と薬物代謝酵素CYP3A阻害活性(ポスター発表の部)

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Pleurospermum rivulorum 'Yunnan Qiang Huo' is a Chinese fork medicine used as an antipyretic, analgesic and diaphoretic agent in local areas of Yunnan province, China. We investigated the constituents of the underground part of this plant and isolated four new bicoumarins, rivulobirins A-D and two new tricoumarins, rivulotririns A and B. Their structure were established by chemical and spectral evidences including HMBC and NOESY experiments. Further, the eleven furanocoumarin derivatives isolated from this plant were examined the inhibitory effects on CYP3A activity. As a result, the must furanocoumarins examined showed inhibitory effect on CYP3A activity and the dimer derivatives rivulobirin A, C and D, and the trimer derivative rivulotririn A showed especially strong inhibitory effects, with an IC_<50> value similar to that of the typical CYP3A inhibitor ketokonazole.
天然有機化合物討論会の論文
1999-09-01