Extra-Weak Chemiluminescence of Drugs. IX. : Extra-Weak Chemiluminescene of Neocarzinostatin Injection

概要

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The extra-weak chemiluminescence (CL) of the antitumor antibiotic neocarzinostatin (NCS) in buffer was measured in order to evaluate the stability of NCS injection. Under conditions where NCS is labile, such as heat treatment, high pH or the presence of a thiol compound, NCS generated higher extra-weak CL than under conditions where it is stable (0.1 M acetate buffer pH 4.0). On the other hand, the extra-weak CL generated from NCS in buffer decreased in the presence of disaccharides such as sucrose and maltose, which are known to stabilize NCS. This CL measurement may be used as a monitor for evaluating the stability of injections as well as solid drugs such as tablets, capsules, etc., as reported previously (Mizugaki et al., 1985).
社団法人日本薬学会の論文
1988-11-25