コリン作働薬の分子座標解析法による構造-活性相関(A 基礎的研究)(II 予防および治療)

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概要

• 論文の詳細を見る

• In connection with the synthesis and design of hypotensive cholinergic agents, the authors attempted to study structure-activity relationship of them by a new method, named molecular coordinate analysis. Key atoms corresponding to the terminal methyl carbon, etheric oxygen (Oa), carbonyl oxygen (Ob), and the ammonium nitrogen (N^+) on the other end of Ach were chosen from cholinergic compounds. Common coordinates of the atoms of three compounds (1,8,15) which contain partially fixed skeletons were found by calculation with computer. Conformations of the other agents were calculated to give digital data and three-dimensional projection patterns. On the basis of the results, some conclusions on the structure-activity relationship were drawn.

• 近畿大学の論文
• 1980-09-25

著者

• 竹村 庄司

  Faculty Of Pharmaceutical Sciences Kinki University

• 竹村 庄司

  近畿大学薬学部医薬品化学教室

• 三木 康義

  近畿大学薬学部医薬品化学教室

• 三木 康義

  近畿大学 薬学部

• 竹村 庄司

  Faculty of Pharmaceutical Sciences, Kinki University

• 三木 康義

  近畿大学薬学部

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