Studies on Benzhydryl Derivatives. IV. Synthesis and Anti-inflammatory Activity of 2-O-(Diphenylacetyl)salicylic Acids

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概要

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• A synthetic route to 2-O-(diphenylacetyl)salicylic acid derivatives was developed and the effects of the products on the heat-denaturation of albumin and on heat-induced erythrocytolysis were examined (in vitro anti-inflammation test). Trichloroethyl salicylate was acylated with diphenylacetic acid and its derivatives in the presence of methanesulfonyl chloride and pyridine, and the products were deprotected with zinc-acetic acid to give 2-O-(diphenylacetyl)salicylic acid derivatives. Their biological effects resembled those of ibuprofen.

• 公益社団法人日本薬学会の論文
• 1983-08-25

著者

• 竹村 庄司

  Faculty Of Pharmaceutical Sciences Kinki University

• 三木 康義

  Faculty of Pharmaceutical Sciences, Kinki University

• 吾妻 由子

  Faculty of Pharmaceutical Sciences, Kinki University

• 正垣 千幸

  Faculty of Pharmaceutical Sciences, Kinki University

• 永富 光

  General Research Center, Funai Pharmaceutical Co., Ltd.

• 安井 凡平

  General Research Center, Funai Pharmaceutical Co., Ltd.

• 安藤 和子

  General Research Center, Funai Pharmaceutical Co., Ltd.

• 安藤 和子

  General Research Center Funai Pharmaceutical Co. Ltd.

• 三木 康義

  Faculty Of Pharmaceutical Sciences Kinki University

• 吾妻 由子

  Faculty Of Pharmaceutical Sciences Kinki University

• 正垣 千幸

  Faculty Of Pharmaceutical Sciences Kinki University

• 三木 康義

  近畿大学 薬学部

• 安井 凡平

  General Research Center Funai Pharmaceutical Co. Ltd.

• 永富 光

  General Research Center Funai Pharmaceutical Co. Ltd.

• 竹村 庄司

  Faculty of Pharmaceutical Sciences, Kinki University

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