Reaction of 2-Methyl-4-phenyl-2,3-dihydro-1H-pyrazolo[2,3,4-de][1,5]-naphthyridine 2-Oxides with Acetic Anhydrides : Polonovski Reaction versus Mesomeric Betaine Formation
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概要
- 論文の詳細を見る
Treatment of 2-methyl-4-phenyl-2,3-dihydro-1H-pyrazolo[2,3,4-de][1,5]naphthyridine 2-oxide (10a) with acetic anhydride and triethylamine or trifluoroacetic anhydride (TFAA) in the presence of dimethyl acetylenedicarboxylate (DMAD) gave the Polonovski reaction products 11-14 as the major products. The 3,4-diphenyl derivative 10b, when treated with acetic anhydride and triethylamine either in the presence or the absence of DMAD, gave only the O-acetylhydroxylamine 17,while treatment of the same N-oxide 10b with TFAA in the presence of DMAD at -20℃ afforded the expected cycloadduct 22 as the major product.
- 公益社団法人日本薬学会の論文
- 1986-09-25
著者
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竹村 庄司
Faculty Of Pharmaceutical Sciences Kinki University
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三木 康義
Faculty of Pharmaceutical Sciences, Kinki University
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池田 正澄
Kyoto Pharmaceutical University
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富井 修
Faculty of Pharmaceutical Sciences, Kinki University
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宇都宮 美佐
Faculty of Pharmaceutical Sciences, Kinki University
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池田 正澄
Japan and Kyoto Pharmaceutical University
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三木 康義
Faculty Of Pharmaceutical Sciences Kinki University
-
富井 修
Faculty Of Pharmaceutical Sciences Kinki University
-
宇都宮 美佐
Faculty Of Pharmaceutical Sciences Kinki University
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三木 康義
近畿大学 薬学部
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竹村 庄司
Faculty of Pharmaceutical Sciences, Kinki University
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