Carbamoylmethl Radical Cyclization : Formal Synthesis of (-)-Trachelanthamidine

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概要

• 論文の詳細を見る

• Tributyltin hydride-mediated radical cyclization of the (2S)-N-(α-chloroacetyl)-2-ethenylpyrrolidines 13a, b and 15 and the bis(phenylthio)acetyl congener-14 derived from (S)-prolinol gave (1R, 7aS)-hexahyrdo1-methyl-3H-pyrrolizin-3-one (17) and its derivatives 16a, b in highly regio- and diastereo-selective manner. This radical cyclization was successfully applied to the formal total synthesis of (-)-trachelanthamidine.

• 社団法人日本薬学会の論文
• 1992-09-25

著者

• 池田 正澄

  Kyoto Pharmaceutical University

• 池田 正澄

  京都薬科大学

• 石橋 弘行

  Kyoto Pharmaceutical University

• 石橋 弘行

  金沢大学薬学部

• 石橋 弘行

  京都薬科大学

• 佐藤 達典

  京都薬科大学

• 佐藤 達典

  Kyoto Pharmaceutical University

• 辻本 勝博

  Kyoto Pharmaceutical University

• 松林 賢一郎

  Kyoto Pharmaceutical University

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