ラジカル環化反応における位置及び立体化学の制御と天然物合成
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概要
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This review summarizes our recent studies on the synthesis of nitrogencontaining heterocycles using cyclizations of N-alkenylcarbamoylmethyl radicals. These reactions are classified into several types of ring closures including relatively difficult 4-exo-trig and 5-endo-trig cyclizations which provide β- and γ-lactams, respectively. Sulfur-controlled exo-selective aryl radical cyclizations onto enamides and radical translocation/cyclization of aryl radicals generated from 2-alkenyl- or 2-alkynyl-N-(o-halobenzoyl) pyrrolidines are also described. The particular emphasis has been placed on the applications of these methods to the synthesis of natural products.
- 公益社団法人日本薬学会の論文
- 1997-12-01
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関連論文
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