Convenient Synthesis of 4-Alkyl, Alkenyl, and Alkynyl Substituted N-(Phenylsulfonyl)indoles

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概要

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• The indolone 1 reacted with organomagnesium or lithium reagents to give the carbinols 6 and 10,which, upon treatment under appropriate acidic conditions or neutral thermal conditions, gave the 1-phenylsulfonylindoles 8 and 11 bearing various kinds of alkyl, alkenyl, and alkynyl substituents at the 4-position. The indolone 1 was also converted to the 4-cyanoindole 14 via the cyanohydrin O-trimethylsilyl ether 13.

• 社団法人日本薬学会の論文
• 1994-10-15

著者

• 池田 正澄

  Kyoto Pharmaceutical University

• 池田 正澄

  京都薬科大学

• 石橋 弘行

  Kyoto Pharmaceutical University

• 石橋 弘行

  金沢大学薬学部

• 石橋 弘行

  京都薬科大学

• 赤松 進

  Kyoto Pharmaceutical University

• 入山 浩子

  Kyoto Pharmaceutical University

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