Total Synthesis of Avellanins A and B, New Fungal Metabolites from Hamigera avellanea with Pressor Effect
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概要
- 論文の詳細を見る
Avellanins A and B (1 and 2), new pressor-active fungal metabolites from Hamigera avellanea, have been conveniently synthesized from methyl anthranilate. This synthetic study has established the absolute stereostructure of avellanin B (2). Coupling of methyl anthranilate with N-protected amino acid derivatives was best carried out by use of ((9-fluorenylmethyl)oxy)carbonyl (Fmoc)-amino acid chloride. Chain elongation for avellanins was accomplished with diethyl phosphorocyanidate, while cyclization was achieved with diphenyl phosphorazidate.
- 社団法人日本薬学会の論文
- 1989-04-25
著者
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中尾 一成
名市大・薬
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塩入 孝之
名市大・薬
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中尾 一成
Faculty of Pharmaceutical Sciences, Nagoya City University
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浜田 康正
Faculty of Pharmaceutical Sciences, Nagoya City University
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塩入 孝之
Faculty of Pharmaceutical Sciences, Nagoya City University
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塩入 孝之
名城大院・総合学術
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塩入 孝之
Faculty Of Pharmaceutical Sciences Nagoya City University
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塩入 孝之
名古屋市大・薬
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