8 PhenylalanineからTropic acidへの非酵素的転換反応
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概要
- 論文の詳細を見る
It has been previously shown that phenylalanine is a precursor of tropic acid (I) in Datura Stramonium plants. We have found that tropic acid is formed from phenylalanine or its ethyl ester by its chemical deamination with nitrous acid through 1, 2-migration of phenyl group (T. L., 1967, 3007; 1971, 2283, 2287). For the extension of this work, atropine and apoatropine were obtained by the deamination of IV with sodium nitrite in dilute sulfuric acid. When L-phenylalanine was deaminated with sodium nitrite in trifluoroacetic acid, S(-)-tropic acid which shows the same absolute configuration with natural tropic acid, was obtained, on the other hand, the deamination of L-phenylalanine ethyl ester gave antipodal R(+)-tropic acid.
- 天然有機化合物討論会の論文
- 1971-10-01
著者
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塩入 孝之
Faculty of Pharmaceutical Sciences, Nagoya City University
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竹内 義雄
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Koga Kenjiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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古賀 憲司
東大薬
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阿知波 一雄
東大薬
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山田 俊一
東大薬
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塩入 孝之
東大薬
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北川 富造
東大薬
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竹内 義雄
東大薬
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呉 欽敬
東大薬
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呉 欽敬
Faculty Of Pharmaceutical Sciences University Of Tokyo
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