ASYMMETRIC α-ALKYLATION OF CYCLOHEXANONE BY MEDIATION OF A CHIRAL LIGAND AND THE LEAVING-GROUP EFFECT OF ELECTROPHILES ON ENANTIOSELECTIVITY
スポンサーリンク
概要
- 論文の詳細を見る
By the mediation of a chiral amino ether (4), the asymmetric α-benzylation of cyclohexanone (1) was effected via an achiral lithioenamine (6) to give α-benzylcyclohexanone (3) in up to 52% ee. A dramatic leaving-group effect of electrophiles on enantioselectivity was also observed.
- 公益社団法人日本薬学会の論文
- 1989-04-25
著者
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古賀 憲司
Faculty of Pharmaceutical Sciences, University of Tokyo
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新藤 充
東大・薬
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Koga Kenjiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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富岡 清
Faculty of Pharmaceutical Sciences, University of Tokyo
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富岡 清
京都大学大学院薬学研究科
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新藤 充
Faculty of Pharmaceutical Sciences, University of Tokyo
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