Functionalized Macrocycles. I. Synthesis of Thiol-bearing Crown Ethers as an Approach to Regioselective Catalysts

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概要

• 論文の詳細を見る

• The rates of transacylation were studied between crown ethers (1,2,3) having sulfhydryl groups at the end of side arms of different lengths and α-, β-, γ-, and ε-amino acid p-nitrophenyl ester salts (4,6,7,8). It was shown that regioselectivity of the reaction can be successfully correlated with the distance of the catalytic site from the polyether ring. It was also shown that introduction of ether oxygen in the side arm can be used to keep the side arm sticking up from the polyether ring in the complex.

• 公益社団法人日本薬学会の論文
• 1979-10-25

著者

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• 松井 武明

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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