Stereoselective Reactions. XII. : Synthesis of Antitumor-Active Steganacin Analogs, Picrosteganol and Epipicrosteganol, by Selective Isomerization

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概要

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• New steganacin analogs with definite absolute configurations, (-)-picro- and (-)-epipicrosteganol, were synthesized by isomerization of (-)-steganol and (-)-episteganol, respectively, at the α-position to the lactone carbonyl. The structure of (-)-epipicrosteganol was confirmed by X-ray crystallographic analysis. Selective epimerization at the C-4 benzylic position was observed upon acidic treatment of (-)-steganacin, giving (-)-episteganacin.

• 公益社団法人日本薬学会の論文
• 1986-04-25

著者

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• 富岡 清

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 富岡 清

  京都大学大学院薬学研究科

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 石黒 恒男

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 石黒 恒男

  Central Research Laboratories Ajinomoto Co. Inc.

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