Stereochemical Studies. XXXI. Total Synthesis of Several D-Pentose Derivatives. Stereochemical Courses of the Synthesis of Four Methyl 2,3-Anhydro-5-O-benzyl-D-pentofuranosides from L-Glutamic Acid and Their Reactions with Nucleophiles

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概要

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• Stereoselective synthesis of several D-pentose derivatives from L-glutamic acid without resolution step was performed. Isolation of all possible isomers of methyl 2,3-anhydro-5-O-benzyl-D-pentofuranosides and their reactions leading to deoxy, amino, and thio derivatives were discussed on the stereochemical ground. Examples in which methoxy group at C_1 exhibits more steric hindrance in the reactions than the benzyloxymethyl group at C_4 are presented.

• 公益社団法人日本薬学会の論文
• 1974-10-25

著者

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• 谷口 誠朗

  東大薬

• 谷口 誠朗

  Faculty of Pharmaceutical Sciences, University of Tokyo

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