Stereoselective Reactions. XX. Synthetic Studies on Optically Active β-Lactams. III. Stereocontrolled Synthesis of Chiral Intermediate to (+)-Thienamycin from D-Glucose
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概要
- 論文の詳細を見る
A chiral key intermediate (19a) for the synthesis of (+)-thienamycin was synthesized starting from D-glucose. The enol ether 13,obtained from the ketone 11 by Horner-Wittig reaction, was transformed to the corresponding methyl ester 16 by pyridinium chlorochromate oxidation or by employing the Wacker process. The ester 16 was further converted to the β-lactam 19a, which is a useful chiral precursor to (+)-thienamycin.
- 公益社団法人日本薬学会の論文
- 1991-09-25
著者
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古賀 憲司
Faculty of Pharmaceutical Sciences, University of Tokyo
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伊古田 暢夫
放射線医学総合研究所重粒子医科学センター
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古賀 憲司
東京大学
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Koga Kenjiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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吉野 収
(present Address)national Institute Of Radiological Sciences
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伊古田 暢夫
(Present address)National Institute of Radiological Sciences
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伊古田 暢夫
National Institute Of Radiological Sciences
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