Synthesis of (-)-Swainsonine and (-)-8-epi-Swainsonine from (S)- and (R)-Glutamic Acid Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
(-)-Swainsonine (1) and (-)-8-epi-swainsonine were synthesized from (S)- and (R)-glutamic acid derivatives. (2R, 3S, 4R)-3,4-Dihydroxy-2-hydroxymethylpyrolidine derivatives (9a and 9b) were prepared by cis-dihydroxylation of α, β-unsaturated compounds 6,10 and 15 with OsO_4 as the key reaction. The diastereoselective allylation of the aldehydes 18 derived from 9a and 9g, followed by cyclization, gave 1 and (-)-8-epi-swainsonine.
- 公益社団法人日本薬学会の論文
- 1990-10-25
著者
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伊古田 暢夫
放射線医学総合研究所
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花木 昭
National Institute of Radiological Sciences
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伊古田 暢夫
放射線医学総合研究所重粒子医科学センター
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花木 昭
Faculty Of Engineering Shizuoka University
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Hanaki A
Faculty Of Engineering Shizuoka University
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Ikota Nobuo
Research Center For Radiation Emergency Medicine National Institute Of Radiological Sciences
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伊古田 暢夫
National Institute of Padiological Sciences
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Ikota Nobuo
Redox Regulation Research Group National Institute Of Radiological Sciences
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