Reactions of Superoxide Ion with Redox-Active Substances of Physiological Importance : Generation of Semiquinone Radicals from Physiologically Important Quinones

概要

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The reactions of superoxide ion, O_2^-, with physiologically important quinones were investigated in acetonitrile by electron spin resonance (ESR) spectroscopy. Superoxide ion could reduce quinones such as p-benzoquinone, duroquinone, vitamin E quinone, 1,4-naphthoquinone and vitamin K_3 to yield the corresponding semiquinone radicals. The fact that vitamin E quinone, an irreversible metabolite of vitamin E, was reduced by O_2^- to the semiquinone radical suggests that, like vitamin E, vitamin E quinone may also scavenge O_2^- and protect living cells from the effects of O_2^- in a hydrophobic environment. Further, in view of the apparent reversiblity of the reaction of O_2^- with vitamin K_3,it is unlikely that the in vivo toxicity of vitamin K_3 is solely due to O_2^- production, as has been suggested.
公益社団法人日本薬学会の論文
1983-08-25