Production of Hydroxyl Radicals from the Reactions of Some Copper(II) Complexes with Hydrogen Peroxid : Ligand Exchange Effects of Copper(II) Complexes on the Activation of Hydrogen Peroxide
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概要
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The reactions of Cu^<II>(en)_2 (en : ethylenediamine) with hydrogen peroxide (H_2O_2) during the successive addition of a polyamine-N-polycarboxylate such as ida (iminodiacetic acid) and edta (ethylenediaminetetraacetic acid) were investigated by the thiobarbituric acid (TBA) method and by the electron spin resonance (ESR) titration method. A relatively good relation between TBA method and ESR titration method was observed.The ligand, en, in Cu^<II>(en)_2 was easily replaced by ida and edta. In the case of edta, which is a tetradentate ligand, Cu^<II>(edta) was formed when the concentration ratio of edta to Cu^<II>(en)_2 was 1. On the other hand, in the case of ida which is a bidentate ligand, the reactions between Cu^<II>(en)_2 and ida proceeded stepwise. That is, one is the formation of a mixed ligand complex of Cu(II), Cu^<II>(en)(ida), when the concentration ratio of ida to Cu^<II>(en)_2 was 1. The other is the formation of Cu^<II>(ida)_2 when the concentration ratio of ida to Cu^<II>(en)_2 was 2.A mixed ligand complex, Cu^<II>(en)(ida), exhibited activity towards H_2O_2,whereas Cu^<II>(ida)_2 and Cu^<II>(edta) did not show any activity towards H_2O_2. The different reactivities of these Cu(II) complexes toward H_2O_2 were discussed.
- 公益社団法人日本薬学会の論文
- 1992-05-25
著者
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小沢 俊彦
放射線医学総合研究所
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小澤 俊彦
放射線医学総合研究所:横浜薬科大学
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花木 昭
Faculty Of Engineering Shizuoka University
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Hanaki A
Faculty Of Engineering Shizuoka University
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小沢 俊彦
Division of Chemical Pharmacology, National Institute of Radiological Sciences
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花木 昭
Division of Chemical Pharmacology, National Institute of Radiological Sciences
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高澤 文恵
Kyoritsu College of Pharmacy
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