Synthesis of (2R, 3S, 4S)-3,4-Dihydroxy-2-hydroxymethylpyrrolidine and Polyoxamic Acid Derivatives from (S)-Pyroglutamic Acid
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概要
- 論文の詳細を見る
(2R, 3S, 4S)-3,4-Dihydroxy-2-hydroxymethylpyrrolidin (6) and polyoxamic acid (20) were synthesized from (S)-pyroglutamic acid derivatives (1 and 7). The key reactions are the selective mono-O-benzylation of 1 and 7,and subsequent Mitsunobu reaction to invert the stereochemistry of the free hydroxy group of 3 and 11.
- 公益社団法人日本薬学会の論文
- 1989-12-25
著者
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伊古田 暢夫
放射線医学総合研究所重粒子医科学センター
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伊古田 暢夫
National Institute of Padiological Sciences
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伊古田 暢夫
National Institute Of Radiological Sciences
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