synthesis of (3R, 4R, 5R)-1-(tert-Butoxycarbonyl)-3,4-isopropylidenedioxy-5-methoxymethyl-2-pyrrolidinone from (S)-Pyroglutaminol
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概要
- 論文の詳細を見る
(3R, 4R, 5R)-1-(tert-Butoxycarbonyl)-3,4-isopropylidenedioxy-5-methoxymethyl-2-pyrrolidinone (6), a useful chiral intermediate for the preparation of calyculins, was synthesized starting from (S)-pyroglutaminol via the O-methylation of 1c with diazomethane in the presence of fluoboric acid and cis-dihydroxylation of the α, β-unsaturated lactam (4) as the key reactions.
- 公益社団法人日本薬学会の論文
- 1992-07-25
著者
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伊古田 暢夫
放射線医学総合研究所重粒子医科学センター
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伊古田 暢夫
National Institute of Padiological Sciences
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伊古田 暢夫
National Institute Of Radiological Sciences
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