Radioprotective Effect of Chitosan in Sub-lethally X-ray IrradiatedMice.

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概要

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• The radioprotective effect of chitosan was studied in mice following whole-body X-ray irradiation. C3H/ He mice were exposed to 7 Gy, and their survival rates were examined. The survival rates of chitosan- diet mice were about 20% higher than those of mice on a standard diet, and the rates dropped sharply to a plateau at day 10 after X-ray irradiation. The chitosan-diet mice had an increased weight ratio of spleen to body within the experimental period. The leukocyte, thrombocyte, and erythrocyte counts as well as the hematocrit and hemoglobin levels were recovered significantly and more rapidly in the chitosan-diet mice than the standard-diet mice at day 14 after irradiation. The scavenging abilities of chitosan were evaluated by the ESR spin-trapping method. These observations suggested that chitosan led to hematopoetic activation and leukocytogenesis in mice after sub-lethal dose irradiation, and that the biological response might be caused by radical trapping or scavenging.

• 日本放射線影響学会の論文

著者

• 伊古田 暢夫

  放射線医学総合研究所

• OZAWA Toshihiko

  Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiolo

• IKOTA Nobuo

  Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiolo

• IKOTA Nobuo

  School of Pharmacy, Shujitsu University

• 伊古田 暢夫

  放射線医学総合研究所重粒子医科学センター

• Ishigure Nobuhito

  Env. Toxic. Sci. Cent. Radiat. Safety Nat. Inst. Rad. Sci.(nirs)

• KIM Young-Sook

  Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• Kim H

  Radiation Health Research Institute Korea Hydro And Nuclear Power Corporation

• OZAWA Toshihiko

  Department of Health Pharmacy, Yokohama College of Pharmacy

• Ikota Nobuo

  Research Center For Radiation Emergency Medicine National Institute Of Radiological Sciences

• Yoshikawa M

  Environmental Radiation Protection Research Group National Institute Of Radiological Sciences

• NISHIMURA YOSHIKAZU

  Environmental Radiation Protection Research Group, National Institute of Radiological Sciences

• KIM HEE-SUN

  Radiation Health Research Institute, Korea Hydro and Nuclear Power Corporation

• ARIMA HIROMI

  Redox Regulation Research Group, National Institute of Radiological Sciences

• BOM HEE-SEUNG

  Division of Nuclear Medicine, Chonnam University Hospital

• KIM YOUNG-HO

  Division of Nuclear Medicine, Chonnam University Hospital

• WATANABE YOSHITO

  Environmental Radiation Protection Research Group, National Institute of Radiological Sciences

• YUKAWA MASAE

  Environmental Radiation Protection Research Group, National Institute of Radiological Sciences

• NISHIMURA Yoshikazu

  National Institute of Radiological Sciences

• Kim Hee-sun

  放射線医学総合研究所

• Arima Hiromi

  Redox Regulation Research Group National Institute Of Radiological Sciences

• Kim Young-ho

  College Of Pharmacy Chungnam National University

• Bom Hee-seung

  Division Of Nuclear Medicine Chonnam University Hospital

• Ishii Nobuyuki

  Env. Toxic. Sci. Cent. Radiat. Safety Nat. Inst. Rad. Sci.(nirs)

• Ikota Nobuo

  Redox Regulation Research Group National Institute Of Radiological Sciences

• Nishimura Yoshikazu

  Environmental Radiation Protection Research Group National Institute Of Radiological Sciences

• Nishimura Yoshikazu

  放射線医学総合研究所

• Nishimura Yoshikazu

  Nati. Inst. Radiol. Sci.

• Ozawa Toshihiko

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Ozawa Toshihiko

  Redox Regulation Research Group National Institute Of Radiological Sciences

• Watanabe Yoshito

  放射線医学総合研究所

• Watanabe Yoshito

  Environmental Radiation Protection Research Group National Institute Of Radiological Sciences

• Watanabe Yoshito

  Environ. Radiat. Protect. Group Nirs

• Watanabe Yoshito

  Division Of Human Radiation Environment National Institute Of Radiological Science

• Yukawa Masae

  Environmental Radiation Protection Research Group National Institute Of Radiological Sciences

• Ozawa Toshihiko

  放射線医学総合研究所重粒子医科学センター 粒子線生物研究グループ

• Yukawa Masae

  放射線医学総合研究所

• Kim Young-sook

  Functional Metabolites Research Center Kribb

• Kim Hee-sun

  Radiation Health Research Institute Korea Hydro And Nuclear Power Corporation

• Kim Y‐h

  Division Of Nuclear Medicine Chonnam University Hospital

• Kim Young-ho

  Division Of Materials Science & Engineering Hanyang University

• Watanabe Yoshito

  Natl. Irist Radiol. Sci.

• Kim Young-ho

  Division Of Biotechnology College Of Environmental & Bioresource Sciences Chonbuk National University

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