Recent Progress in In Vivo ESR Spectroscopy

スポンサーリンク

概要

• 論文の詳細を見る

• The generation of free radicals and redox status is related to various diseases and injuries that are related to radiation, aging, ischemia-reperfusion, and other oxidative factors. In vivo electron spin resonance (ESR) spectroscopy is noninvasive and detects durable free radicals in live animals. ESR spectrometers for in vivo measurements operate at a lower frequency (〜3.5GHz, 〜1GHz, 700MHz, and 〜300MHz) than usual (9-10GHz). Several types of resonators have been designed to minimize the dielectric loss of electromagnetic waves caused by water in animal bodies. In vivo ESR spectroscopy and its imaging have been used to analyze radical generation, redox status, partial pressure of oxygen and other conditions in various disease and injury models related to oxidative stress with probes, such as nitroxyl radicals. Through these applications, the clarification of the mechanisms related to oxidative diseases (injuries) and the accumulation of basic data for radiological cancer therapy are now ongoing. In vivo ESR measurement is performed in about 10 laboratories worldwide, including ours. To introduce in vivo ESR spectroscopy to life scientists, this article reviews the recent progress of in vivo ESR spectroscopy in instrumentation and its application to the life sciences.

• 日本放射線影響学会の論文
• 2004-10-10

著者

• OZAWA Toshihiko

  Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiolo

• Takeshita Keizo

  Redox Regulation Research Group National Institute Of Radiological Sciences

• Ozawa Toshihiko

  Redox Regulation Research Group National Institute Of Radiological Sciences

関連論文

• Scandium Ion-accelerated Scavenging Reaction of Cumylperoxyl Radical by a Cyclic Nitroxyl Radical via Electron Transfer
• EPR Study on Stable Magnesium Complexes of the Phenoxyl Radicals Derived from a Vitamin E Model and Its Deuterated Derivatives
• Radioprotective Effect of Chitosan in Sub-lethally X-ray IrradiatedMice.
• Selective Scavenging Property of the Indole Moiety for the Nitrating Species of Peroxynitrite
• A Long-lived o-Semiquinone Radical Anion is Formed from N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), an Insect-derived Antibacterial Substance
• Quantitative Measurements of Oxidative Stress in Mouse Skin Induced by X-Ray Irradiation
• Nitration of Specific Tyrosine Residues of Cytochrome c Is Associated with Caspase-Cascade Inactivation(Biochemistry)
• In Vivo Nitric Oxide Production and iNOS Expression in X-Ray Irradiated Mouse Skin(Miscellaneous)
• Recent Progress in In Vivo ESR Spectroscopy

スポンサーリンク