Whole-body retention and fetal uptake of ^<65>Zn in pregnant mice fed a Zn-deficient diet

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Whole-body retention and fetal uptake of ^<65>5Zn under a Zn-deficient diet were studied in pregnant mice in the late gestational stage after a single oral administration of ^<65>Zn. Whole-body retentions were much greater in mice given a Zn-deficient diet than in those given a Zn-normal diet. Accordingly, the amount of ^<65>Zn transmitted to the offspring in utero was greater in the Zn-deficient diet group. In another experiment, fetal uptake of ^<65>Zn in dams on gestation day 17 was examined over a period of 24 hr after a single intravenous administration of ^<65>Zn to the Zn-deficient and Zn-normal animals. There was no major difference in fetal uptake between the two groups, indicative that approximately a similar proportion of the ^<65>Zn retained in the maternal body was transmitted to the in utero offspring in both groups.
日本放射線影響学会の論文