Milk Secretion of Inorganic Mercury in Lactatlng Goats

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Three lactating goats were administered with a single dose of 1 mCi of ^<203>Hg intravenously. The ^<203>Hg concentration in the blood and milk, and its excretion rate in urine and feces, were investigated. The ^<203>Hg concentration in the whole blood was 5.5x10^<-3>% of dose/g 1 hr after administration and decreased with time to 5.0x10^<-5>% of dose/g 21 days after administration. On the other hand, the concentration in the milk reached a peak value of 5.7x10^<-4>% of dose/g 5 hrs after administration, followed by a gradual decrease to 5.0x10^<-6>% of dose/g 21 days after administration. The ^<203>Hg concentration in the blood serum was higher than that in the red blood cells until the initial 5 hrs after administration. This relation was reversed thereafter. The ^<203>Hg concentration in the milk casein was higher than that in the whey. The milk casein showed a peak value of 1.2x10^<-3>% of dose/g at 5 hrs after administration. The cumulative amounts of ^<203>Hg discharged in the milk, and in the urine and feces for 21 days after administration, were about 0.9, 12 and 30 % of dose, respectively. The biological half life of ^<203>Hg in these goats was estimated to be 26 days.
日本放射線影響学会の論文