Whole-Body Retention of 60CoCl2 and 58Co-Cyanocobalamin in Young and Adult Rats

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The whole-body retention of ^<60>CoCl_2 and ^<58>Co-cyanocobalamin after oral and intravenous administration was investigated in young and adult rats. The whole-body retention of ^<58>Co-cyanocobalamin was considerably higher than that of ^<60>CoCl_2 in rats of all age groups and the younger rat showed higher retention of both CoCl_2 and cyanocobalamin than the adult rat. The biological half life in slowly decreasing phase after oral administration of ^<60>CoCl_2 and ^<58>Co-cyanocobalamin was approximately equal among all age groups and estimated to be about 10 and 25 days, respectively. These results suggested that the whole-body retention of orally administered ^<60>CoCl_2 and ^<58>Co-cyanocobalamin in rats of various ages depends mainly on the intestinal absorption rather than endogenous excretion rate. The excretion pattern of ^<58>Co-cyanocobalamin,i.e., F/U ratio etc., is very different from that of inorganic cobalt and it is therefore assumed that ^<58>Co-cyanocobalamin is rather stable in the body.
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