ラットにおけるカリウムの回転率におよぼす年齢の影響

概要

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The turnover rate of potassium in the rat with special reference to age ofthe animal was investigated by means of tracer study and balance study. Tracer studyrevealed that the older animals laave a longer biological half-life and higher body retentionfor intraperitoneally dosed "K than the younger animals, Balance study was done bydetermining the body burden and daily intake of stable potassium for rats of various agesby using atomic absorption spectrometry. The turnover rate of potassium was calculatedfrom these data on the assumption that the body is practically a single compartment forpotassium kinetics. For the calculation the changes of body burden and daily intake ofpotassium versus age were expressed by a Gompertz function and a exponential function,respectively. The result was nearly the same as that of tracer study. The age trend ofthese results are in good agreement with those obtained for radiocesium in the previousinvestigations. It is therefore reasonably assumed that the turnover rate of radiocesium isclosely related to that of potassium.
社団法人日本獣医学会の論文
1974-06-25