Neuroprotective Activity of p-Terphenyl Leucomentins from the Mushroom Paxillus panuoides(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H_2O_2 neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H_2O_2, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.
- 社団法人日本農芸化学会の論文
- 2003-08-23
著者
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Ryoo I‐j
Korea Res. Inst. Of Bioscience And Biotechnology
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Kim J‐p
Laboratory Of Antioxidants Korea Research Institute Of Bioscience And Biotechnology
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YUN Bong-Sik
Korea Research Institute of Bioscience and Biotechnology
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RYOO In-Ja
Korea Research Institute of Bioscience and Biotechnology
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YOO Ick-Dong
Korea Research Institute of Bioscience and Biotechnology
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Yoo I‐d
Korea Res. Inst. Of Bioscience And Biotechnology
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KIM Jong-Pyung
Korea Research Institute of Bioscience and Biotechnology
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Yun B‐s
Functional Metabolomics Research Center Korea Research Institute Of Bioscience And Biotechnology
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LEE In-Kyoung
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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KIM Young-Sook
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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KIM Young-Ho
College of Pharmacy, Chungnam National University
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Ryoo In-ja
Korea Res. Inst. Of Bioscience And Biotechnology
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Yun Bong-sik
Functional Metabolites Research Center Kribb
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Yun Bong-sik
Korea Research Institute Of Bioscience And Biotechnology Kist. Yusong
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KIM YOUNG-HO
Division of Nuclear Medicine, Chonnam University Hospital
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Kim Y
College Of Pharmacy Chungnam National University
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Kim Young-ho
College Of Pharmacy Chungnam National University
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Yoo Ick-dong
Korea Res. Inst. Of Bioscience And Biotechnology
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Yun Bong-sik
Functional Metabolomics Research Center Korea Research Institute Of Bioscience And Biotechnology
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Lee In-kyoung
Functional Metabolites Research Center Kribb
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Kim Young-sook
Functional Metabolites Research Center Kribb
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Yun B‐s
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Kim Jong-pyung
Microbial Chemistry Research Group Korea Research Institute Of Bioscience And Biotechnology Kist
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Kim Y‐h
Division Of Nuclear Medicine Chonnam University Hospital
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