Selective Cytotoxic Activity of Valinomycin against HT-29 Human Colon Carcinoma Cells via Down-Regulation of GRP78(Pharmacology)
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概要
- 論文の詳細を見る
Glucose deprivation is a fundamental feature of poorly vascularized solid tumors and leads to activation of the molecular chaperone GRP78, which is associated with the unfolded protein response (UPR), a stress-signaling pathway, in tumor cells. We recently isolated an active compound, M126, that inhibits transcription from a GRP78 promoter reporter construct. M126 was identified as valinomycin by various spectroscopic methods. We found that valinomycin prevents UPR-induced protein expression, such as GRP78 and GRP94. The GRPs-inhibitory action of valinomycin severe hypoglycemic and results in selective cell death of the stressed cancer cells. Our findings demonstrate that GRP78 may be an excellent target for the use of cancer chemotherapy in the treatment of solid tumors.
- 社団法人日本薬学会の論文
- 2006-04-01
著者
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Ryoo I‐j
Korea Res. Inst. Of Bioscience And Biotechnology
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SHIN-YA KAZUO
Institute of Molecular and Cellular Biosciences, The University of Tokyo
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Song K‐s
Kyungpook National Univ. Taegu Kor
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Choo Soo‐jin
Functional Metabolomics Research Center Korea Research Institute Of Bioscience And Biotechnology
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BAE Ki-Hwan
College of Pharmacy, Chungnam National University
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Bae Ki-hwan
Department Of Pharmacy Chungnam National University
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Yoo I‐d
Korea Res. Inst. Of Bioscience And Biotechnology
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Shinya K
Biological Information Research Center (birc) National Institute Of Advanced Industrial Science And
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Choo Soo-jin
Functional Metabolomics Research Center Korea Research Institute Of Bioscience And Biotechnology
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RYOO In-Ja
Laboratory of Antioxidant, Korea Research Institute of Bioscience and Biotechnology
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PARK Hae-Ryong
Division of Food Science and Biotechnology, Kyungnam University
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CHOO Soo-Jin
Laboratory of Antioxidant, Korea Research Institute of Bioscience and Biotechnology
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HWANG Ji-Hwan
Division of Food Science and Biotechnology, Kyungnam University
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PARK Young-Min
College of Pharmacy, Chungnam National University
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YOO Ick-Dong
Laboratory of Antioxidant, Korea Research Institute of Bioscience and Biotechnology
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Hwang Ji-hwan
College Of Medicine Cheju National University
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Shin‐ya K
The University Of Tokyo
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Shin-ya Kazuo
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Suzuki Ken-ichi
Astellas Research Service Co. Ltd. Astellas Pharma Inc.
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Bae Ki-hwan
College Of Pharmacy Chung-nam University
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Park Hae-ryong
Division Of Food Science And Biotechnology Kyungnam University
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Park Young-min
College Of Pharmacy Chungnam National University
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Shin‐ya Kazuo
Biomedicinal Information Research Center (birc) National Institute Of Advanced Industrial Science An
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Shin-ya Kazuo
Biomedicinal Information Research Center (birc) National Institute Of Advanced Industrial Science An
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