Trapping Effect of Eugenol on Hydroxyl Radicals Induced by L-DOPA in Vitro
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概要
- 論文の詳細を見る
Many researchers have stated that eugenol might inhibit lipid peroxidation at the stage of initiation, propagation, or both, and many attempts have been made to elucidate the mechanism of its antioxidant activity. Nevertheless, details of its mechanism are still obscure. This study was carried out to investigate the trapping effect of eugenol on hydroxyl radical generated from L-3,4-dihydroxyphenylalanine (DOPA) in MiliQ water and the generation mechanism of the hydroxyl radical by this system which uses no metallic factor. This was studied by adding L-DOPA and 5,5-dimethyl-1-pyrroline N-oxide (DMPO) to phosphate buffered saline (PBS) or MiliQ water, and the generation of hydroxyl radical was detected on an ESR spectrum. By this method, the effect of antioxidants was detected as a modification of ESR spectra. We found that the eugenol trapped hydroxyl radicals directly, because it had no iron chelating action, did not trap L-DOPA semiquinone radical and inhibited hydroxyl radicals with or without iron ion.
- 社団法人日本薬学会の論文
- 2005-09-01
著者
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Song K‐s
Kyungpook National Univ. Taegu Kor
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Urano S
Division Of Biochemistry Shibaura Institute Of Technology
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Urano Shiro
青森大学
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Urano Shiro
芝浦工業大学 生化学
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Urano S
Department Of Applied Chemistry Shibaura Institute Of Technology
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Ogata M
Division Of Microbiology Aomori University
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Ogata Masahiro
芝浦工業大学 生化学
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Urano Shiro
Shibaura Institute Of Technology
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Seki Sachiko
Aomori University
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LI Linxiang
Kyoritsu University of Pharmacy
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ABE Yoshihiro
Kyoritsu University of Pharmacy
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GONDA Ryoko
Kyoritsu University of Pharmacy
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Shin‐ya K
The University Of Tokyo
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OGATA Masahiro
Aomori University
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KANEYA Daisuke
Kyoritsu University of Pharmacy
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SHINYA Kazuo
The University of Tokyo
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LI Linxang
Kyoritsu University of Pharmacy
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KATOH Hironobu
The University of Tokyo
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SEKI Yasuhide
Aomori University
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ENDO Toyoshige
Kyoritsu University of Pharmacy
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SHIN-YA Kazuo
The University of Tokyo, Institute of Molecular and Cellular Biosciences
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ENDO Toyoshige
Faculty of Pharmacy, Keio University
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Endo Toyoshige
Faculty Of Pharmacy Keio University
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Endo Toyoshige
Kyoritsu College Of Pharmacy
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Abe Yoshihiro
Kyoritsu College Of Pharmacy
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Suzuki Ken-ichi
Astellas Research Service Co. Ltd. Astellas Pharma Inc.
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Urano Shiro
Division Of Biochemistry Shibaura Institute Of Technology
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Li Linxiang
Kyoritsu College Of Pharmacy
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Gonda Ryoko
Kyoritsu College Of Pharmac
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Ogata M
Daiichi Seiyaku Co. Ltd. Tokyo Jpn
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Shin‐ya Kazuo
Biomedicinal Information Research Center (birc) National Institute Of Advanced Industrial Science An
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Shin-ya Kazuo
Biomedicinal Information Research Center (birc) National Institute Of Advanced Industrial Science An
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