Antibacterial Activity of Dipropofol and Related Compounds(Pharmacognosy)
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概要
- 論文の詳細を見る
Phenolic compounds, in general, exhibit antioxidant and antibacterial activities. We studied antimicrobial activity of the phenolic antioxidants, propofol (2,6-diisopropylphenol), tocopherol, eugenol, butylated hydroxyanisole (BHA), and several of their dimer compounds. Dipropofol (dimer of 2,6-diisopropylphenol) showed strong antibacterial activity against gram-positive strains including methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococci (VRE), while propofol and other monomeric and dimeric phenols having methyl or tert-butyl groups showed no remarkable activity. The results indicated that the dimeric structure of 2,6-diisopropylphenol moiety may play an important role in the antibacterial activity.
- 社団法人日本薬学会の論文
- 2005-06-01
著者
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Urano S
Division Of Biochemistry Shibaura Institute Of Technology
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Urano Shiro
青森大学
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Urano Shiro
芝浦工業大学 生化学
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Urano S
Department Of Applied Chemistry Shibaura Institute Of Technology
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Ogata M
Division Of Microbiology Aomori University
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Ogata Masahiro
芝浦工業大学 生化学
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Urano Shiro
Shibaura Institute Of Technology
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ENDO Toyoshige
Kyoritsu University of Pharmacy
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OGATA Masahiro
Kyoritsu University of Pharmacy
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ENDO Toyoshige
Faculty of Pharmacy, Keio University
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Endo Toyoshige
Faculty Of Pharmacy Keio University
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Endo Toyoshige
Kyoritsu College Of Pharmacy
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OKA Kentaro
Kyoritsu University of Pharmacy
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SEKI Masako
Kyoritsu University of Pharmacy
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KUNIKANE Takao
Kyoritsu University of Pharmacy
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SATO Kanae
Juntendo University
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HIRAMATSU Keiichi
Juntendo University
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Urano Shiro
Division Of Biochemistry Shibaura Institute Of Technology
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Tutumimoto Sato
Juntendo University
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Seki Masako
Kyoritsu College Of Pharmacy
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Ogata M
Daiichi Seiyaku Co. Ltd. Tokyo Jpn
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Hiramatsu Keiichi
Juntendo Univ. Tokyo
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