Antioxidant Activity of Propofol and Related Monomeric and Dimeric Compounds
スポンサーリンク
概要
- 論文の詳細を見る
This study was carried out to investigate the antioxidant activity of propofol (2, 6-diisopropylphenol) and its related compounds, butylated hydroxyanisole (BHA), 2, 6-dimethylphenol, 2, 6-di-t-butylphenol, and their dimeric compounds. The degree of antioxidant activity was evaluated based on the degree of peroxidation induced with Fe-ascorbic acid in egg phosphatidylcholine through the determination of thiobarbituric acid-reactive substances (TBARS) formed during peroxidation. Their antioxidant activities were in the order of dipropofol>di(2, 6-di-tbutylphenol)>diBHA>di(2, 6-dimethylphenol). Dipropofol, a dimeric compound of propofol, showed the highest antioxidant activities. Dimeric compounds had higher activities than monomeric compounds, and the 1, 1-diphenyl-p-picryhydrazyl-trapping ability of dimeric compounds was also greater than those of monomeric compounds (4-10-fold). These results suggest that dimeric phenols may increase their antioxidant activities along with increments in the conjugation system and play a inhibitory role in the propagation of free radical chain reactions.
- 社団法人日本薬学会の論文
- 2005-03-01
著者
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Song K‐s
Kyungpook National Univ. Taegu Kor
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Urano S
Division Of Biochemistry Shibaura Institute Of Technology
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Urano Shiro
青森大学
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Urano Shiro
芝浦工業大学 生化学
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Urano S
Department Of Applied Chemistry Shibaura Institute Of Technology
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Ogata M
Division Of Microbiology Aomori University
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Ogata Masahiro
芝浦工業大学 生化学
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Urano Shiro
Shibaura Institute Of Technology
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Shin‐ya K
The University Of Tokyo
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ENDO Toyoshige
Kyoritsu University of Pharmacy
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OGATA Masahiro
Kyoritsu University of Pharmacy
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SHINYA Kazuo
University of Tokyo
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ENDO Toyoshige
Faculty of Pharmacy, Keio University
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Endo Toyoshige
Faculty Of Pharmacy Keio University
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Endo Toyoshige
Kyoritsu College Of Pharmacy
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Suzuki Ken-ichi
Astellas Research Service Co. Ltd. Astellas Pharma Inc.
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Urano Shiro
Division Of Biochemistry Shibaura Institute Of Technology
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Ogata M
Daiichi Seiyaku Co. Ltd. Tokyo Jpn
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Shin‐ya Kazuo
Biomedicinal Information Research Center (birc) National Institute Of Advanced Industrial Science An
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Shin-ya Kazuo
Biomedicinal Information Research Center (birc) National Institute Of Advanced Industrial Science An
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Shin-ya Kazuo
University of Tokyo
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