Studies on New Antitumor Antibiotics, Leptofuranins A, B, C and D I. Taxonomy, Fermentation, Isolation and Biological Activities

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概要

• 論文の詳細を見る
• 1996-10-25

著者

• SOHDA Kin-ya

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• HAYAKAWA YOICHI

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• SHIN-YA KAZUO

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• SETO Haruo

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• Song K‐s

  Kyungpook National Univ. Taegu Kor

• Furihata K

  Univ. Tokyo Tokyo Jpn

• Furihata Kazuo

  Graduate School Of Agricultural And Life Sciences University Of Tokyo

• Furihata Kazuo

  Division Of Agriculture And Agricultural Life Science The University Of Agriculture

• Shinya K

  Biological Information Research Center (birc) National Institute Of Advanced Industrial Science And

• FURIHATA Keiko

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• Sohda Kin-ya

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• Sohda Kin-ya

  Drug Metabolism Laboratories Drug Development Division Yamanouchi Pharmaceutical Co. Ltd.

• Shin-ya Kazuo

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• KUZUYAMA Tomohisa

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• Kunigami Toshihiro

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Furihata Kazuo

  Division Of Agriculture And Agricultural Life Sciences

• Yamashita H

  Biotechnology Research Center Toyama Prefectural University

• Hayakawa Y

  Institute Of Low Temperature Science Hokkaido University

• Kunigami T

  Biotechnology Research Center Toyama Prefectural University

• Hayakawa Y

  Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Seto Haruo

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Kuzuyama Tomohisa

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Hayakawa Yoichi

  Institute Of Applied Microbiology The University Of Tokyo

• Seto Haruo

  Institute Of Applied Microbiology The University Of Tokyo

• FURIHATA Keiko

  Institute of Applied Microbiology, The University of Tokyo

関連論文

• JBIR-26, a Novel Natural Compound from Streptomyces sp. AK-AH76, Regulates Mammalian Circadian Clock
• Burkholone, A New Cytotoxic Antibiotic against IGF-I Dependent Cells from Burkholderia sp.
• YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis : II. Physico-chemical Properties and Structure Elucidation
• YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis : I. Fermentation, Isolation and Biological Activities
• Oximidine III, a New Antitumor Antibiotic against Transformed Cells from Pseudomonas sp. II. Structure Elucidation
• Oximidine III, a New Antitumor Antibiotic against Transformed Cells from Pseudomonas sp. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity
• Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neurons from Excitotoxicity : II. Structure Determination
• A Novel Indole-diterpenoid, JBIR-03 with Anti-MRSA Activity from Dichotomomyces cejpii var. cejpii NBRC 103559
• A Novel Nuclear Export Inhibitor JBIR-02, a New Piericidin Discovered from Streptomyces sp. ML55
• Selective Cytotoxic Activity of Valinomycin against HT-29 Human Colon Carcinoma Cells via Down-Regulation of GRP78(Pharmacology)
• Structure of Thioviridamide, a Novel Apoptosis Inducer from Streptomyces olivoviridis
• Thioviridamide, a Novel Apoptosis Inducer in Transformed Cells from Streptomyces olivoviridis
• Studies on Terpenoids Produced by Actinomycetes : Isolation and Structural Elucidation of Antioxidative Agents, Naphterpins B and C
• Deoxyverrucosidin, a Novel GRP78/BiP Down-regulator, Produced by Penicillium sp
• Prunustatin A, a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger
• Structure of Tyroscherin, an Antitumor Antibiotic against IGF-1-dependent Cells from Pseudallescheria sp
• Byssochlamysol, a New Antitumor Steroid against IGF-1-dependent Cells from Byssochlamys nivea II. Physico-chemical Properties and Structure Elucidation
• Byssochlamysol, a New Antitumor Steroid against IGF-1-dependent Cells from Byssochlamys nivea I, taxonomy, Fermentation, Isolation and Biological Activity
• Structure of Aspochalasin H, a New Member of the Aspochalasin Family
• A Novel Neuronal Cell Protecting Substance, Halxazone, Produced by Streptomyces halstedii
• Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neuronal Cells from Excitotoxicity : I. Fermentation, Isolation, Physico-chemical Properties and Biological Activity
• Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothrix sp. : II. Physico-chemical Properties and Structure Elucidation
• Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothrix sp. : I. Production, Isolation and Biological Activity
• Selective Cytotoxicity and Stereochemistry of Aspochalasin D
• Phoenistatin, A New Gene Expression-Enhancing Substance Produced by Acremonium fusigerum
• Rustmicin, a New Macrolide Antibiotic Active Against Wheat Stem Rust Fungus(Organic Chemistry)
• Isolation and Structural Determination of a New Antibiotic Curromycin B
• Spicamycin, a New Differentiation Inducer of Mouse Myeloid Leukemia Cells (Ml) and Human Promyelocytic Leukemia Cells (HL-60)
• Propanosine (K-76), a New Antibiotic Active against Valsa ceratosperma, the Pathogen of Apple Canker Disease
• Taxonomy of Producing Organism, and Production, Isolation, Physico-chemical Properties and Biological Activities of Cirratiomycin A and B
• Phenazostatin C, a New Diphenazine with Neuronal Cell Protecting Activity from Streptomyces sp.
• New Diphenazines with Neuronal Cell Protecting Activity, Phenazostatins A and B, Produced by Streptomyces sp.
• A Novel Versipelostatin Analogue, Versipelostatin F Isolated from Streptomyces versipellis 4083-SVS6
• A Novel Antimycin-like Compound, JBIR-06, from Streptomyces sp. ML55
• Novel GRP78 Molecular Chaperone Expression Down-regulators JBIR-04 and -05 Isolated from Streptomyces violaceoniger
• New Aureothin Derivative, Alloaureothin, from Streptomyces sp. MM23
• Bacillus subtilis ypgA Gene Is fni, a Nonessential Gene Encoding Type 2 Isopentenyl Diphosphate Isomerase
• Trapping Effect of Eugenol on Hydroxyl Radicals Induced by L-DOPA in Vitro
• Antioxidant Activity of Propofol and Related Monomeric and Dimeric Compounds
• Stawamycin Analog, JBIR-11 from Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830
• Total Synthesis of Spiruchostatin A
• P-286 Total Synthesis of Spiruchostatin A
• Novel Antitumor and Neuroprotective Substances Discovered by Characteristic Screenings Based on Specific Molecular Targets
• Diheteropeptin, a Novel Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia : II. Physico-chemical Properties and Structure Elucidation
• Diheteropeptin, a New Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia : I. Production, Isolation and Biological Activities
• Structure of a New Anthracycline, Cinerubin Y, Produced by a Blocked Mutant of Streptomyces violaceochromogenes Transformed by pIJ702(Organic Chemistry)
• A New Depsipeptide Antibiotic, Citropeptin(Microbiology & Fermentation Industry)
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• Rasfonin, a New Apoptosis Inducer in ras-dependent Cells from Talaromyces sp.
• Cytovaricin B, a New Inhibitor of JAK-STAT Signal Transduction Produced by Streptomyces torulosus
• Screening of Microbial Products Modifying the Action of Lepin (Obese Gene Product by a Biosensor)
• Microbial and Chemical Conversion of Antibiotic K-41. I. Isolation and Identification of Conversion Product
• Contribution of N-terminal and Loop Regions of GBP to the Interaction with Epidermal Growth Factor Receptor
• FUNCTION OF INSECT CYTOKINE GBP IN EMBRYOGENESIS OF CABBAGE ARMYWORM, MAMESTRA BRASSICAE(Biochemistry,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• STAGE SPECIFIC AND REGION SPECIFIC EXPRESSION OF INSECT CYTOKINE GBP IN EMBRYO OF CABBAGE ARMYWORM, MAMESTRA BRASSICAE(Biochemistry & Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
• Nucleotide Sequences of Genes Encoding Allosamidin-sensitive and -insensitive Chitinases Produced by Allosamidin-producing Streptomyces(Biochemistry & Molecular Biology)
• A New Screening Method for C-P Compound Producing Organisms by the Use of Phosphoenolpyruvate Phosphomutase(Biological Chemistry)
• Cloning and Expression in Escherichia coli of 2-Hydroxypropylphosphonic Acid Epoxidase from the Fosfomycin-producing Organism, Pseudomonas syringae PB-5123
• Nucleotide Sequence of Fortimicin KL1 Methyltransferase Gene Isolated from Micromonospora olivasterospora, and Comparison of Its Deduced Amino Acid Sequence with Those of Methyltransferases Involved in the Biosynthesis of Bialaphos and Fosfomycin
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• Absolute Configuration of Spicamycin, an Antitumor Antibiotic Produced by Streptomyces alanosinicus
• Structures of New Saponins Isolated from Bupleurum kunmingense Y. Li et S. L. Pan(Organic Chemistry)
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• Isolation and Structure of Isobutyrylleucanicidin Produced by Streptomyces halstedii
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• Isolation and Characterization of 2-Nitroimidazole Produced by Streptomyces Species as an Inhibitor of Both Carbonic Anhydrase and Shell Formation in the Barnacle Balanus amphitrite
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• Detection of the Mevalonate Pathway in Streptomyces Species by Utilization of the 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene
• Carquinostatin B, a New Neuronal Cell-protecting Substance Produced by Streptomyces exfoliatus
• A Novel Neuronal Cell Protecting Substance, Naphthomycinol, Produced by Streptomyces sp. PF7
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• Cinnatriacetins A and B, New Antibacterial Triacetylene Derivatives from the Fruiting Biodies of Fistulina hepatica
• New Ravidomycin Analogues, FE35A and FE35B, Apotosis Inducers Produced by Streptomyces rochei
• A Novel Neuronal Cell Protecting Substance, Aestivophoenin C, Produced by Streptomyces purpeofuscus
• 6-Hydroxytetrangulol, a New CPP32 Protease Inducer Produced by Streptomyces sp.
• A Novel Substance with TGF-β like Activity, Diheteropeptin, Produced by a Fungus, Diheterospora sp.
• Isolation and Structure Elucidation of Novel Neuronal Cell Protecting Substances, Carazomadurins A and B Produced by Actinomadura madurae
• Studies on New Antitumor Antibiotics, Leptofuranins A, B, C and D II. Physicochemical Properties and Structure Elucidation
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• Novel Neuronal Cell Protecting Substances, Aestivophoenins A and B, Produced by Streptomyces purpeofuscus
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• Formobactin, a Novel Radical Scavenging and Neuronal Cell Protecting Substance from Nocardia sp
• Thiopeptide Non-producing Streptomyces Species Carry the tipA Gene : A Clue to Its Function
• Comparison of Two C-P Bond-forming Enzymes Involved in the Biosynthesis of Bialaphos(Biological Chemistry)
• Major Anthocyanin of the Flowers of Hibiscus (Hibiscus rosa-sinensis L.)(Organic Chemistry)
• Growth-phase Dependent Expression of the Mevalonate Pathway in a Terpenoid Antibiotic-producing Streptomyces Strain(Microbiology & Fermentation Technology)
• Cloning of a Gene Cluster Encoding Enzymes Responsible for the Mevalonate Pathway from a Terpenoid-antibiotic-producing Streptomyces Strain(Microbiology & Fermentation Technology)
• The Structure of Enacyloxin II, a Novel Linear Polyenic Antibiotic Produced by Gluconobacter sp. W-315(Organic Chemistry)
• Fluorinated Blasticidin S(Organic Chemistry)
• Crystal Structure of 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase Complexed with Cofactors : Implications of a Flexible Loop Movement upon Substrate Binding
• IDENTIFICATION AND CLONING OF GROWTH-BLOCKING PEPTIDE (GBP) RECEPTOR(Biochemistry,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• Studies on the Biosynthesis of Terpenoidal Compounds Produced by Actinomycetes 2. Biosynthesis of Carquinostatin B via the Non-mevalonate pathway in Streptomyces exfoliatus
• Construction and Characterization of Escherichia coli Disruptants Defective in the yaeM Gene

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